Sinteza substituiranih pirazolidinonov kot prekurzorjev za azometin imine

Klemen, Tajda (author), Štefane, Bogdan (mentor)

Heckova reakcija je reakcija križnega spajanja med alkenom in aril oz. vinil halogenidom. Poteka pod inertno atmosfero z uporabo katalizatorja in baze. Največkrat uporabljeni katalizatorji so paladijevi kompleksi. Sinteza azometin iminov poteka preko pirazolidin-3-onov. Pirazolidin-3-oni so heterociklične spojine, ki smo jih sintetizirali iz različno ß-substituiranih akrilatov z uporabo hidrazin monohidrata. Azometin imine smo pripravili s pretvorbo pirazolidin-3-onov v metanolu in dodatku TFA. Produkti sinteze se bodo uporabili za nadaljnje fotokemijske reakcije.

• Language: Slovenian
• Keywords: Heckova reakcija, akrilati, pirazolidin-3-oni, azometin imini
• Work type: Bachelor thesis/paper
• Typology: 2.11 - Undergraduate Thesis
• Organization: FKKT - Faculty of Chemistry and Chemical Technology
• Year: 2023
• PID: 20.500.12556/RUL-148400
• COBISS.SI-ID: 162858755
• Publication date in RUL: 22.08.2023

Secondary language

• Language: English
• Title: Synthesis of substituted pyrazolidinones as precursors for azomethine imines

Abstract

The Heck reaction is a type of cross-coupling reaction between an alkene and an aryl or vinyl halide. This reaction is carried out under an inert atmosphere using a catalyst and a base. The most frequently used catalysts are palladium complexes. Azomethine imines can be synthesized via pyrazolidine-3-ones. Pyrazolidine-3-ones are heterocyclic compounds that were synthesized from various ß-substituted acrylates using hydrazine monohydrate. Azomethine imines are obtained by converting pyrazolidine-3-ones in methanol and adding TFA. The synthesis products can be utilized for further photochemical reactions.

• Keywords: Heck reaction, acrylates, pyrazolidine-3-ones, azomethine imines