The effects of transcutaneous auricular vagal nerve stimulation on cortical GABAergic and cholinergic circuits : a transcranial magnetic stimulation study

Van Midden, Vesna M. (avtor), Demšar, Jure (avtor), Pirtošek, Zvezdan (avtor), Kojović, Maja (avtor)

Neurophysiological evidence that transcutaneous auricular vagal nerve stimulation (taVNS) affects neuronal signalling at the cortical level is sparse. We used transcranial magnetic stimulation to assess the effect of taVNS on the excitability of intracortical GABAergic and cholinergic circuits. In this within-subject, double-blind study on 30 healthy participants, we used TMS paradigms to assess the effect of a single session of taVNS at 100 Hz and sham earlobe VNS (sVNS) on short-interval intracortical inhibition (SICI) curve and short-latency afferent inhibition (SAI). Control experiment was performed on additional 15 participants using the same experimental settings, but delivering no stimulation (xVNS). Bayesian statistics were used to assess the differences, producing % values that reflect the certainty that the values of interest were decreased during or after stimulation compared with baseline. taVNS increased SICI (96.3%), whereas sVNS decreased SICI (1.2%). SAI was not affected by taVNS, although it was decreased during sVNS (1.34% and 9.1%, for interstimulus intervals 20 and 24 ms, respectively). The changes in TMS parameters detected during sVNS were present in the same direction in the control experiment with no stimulation. Our study provides evidence that taVNS increases the activity of cortical GABAAergic system, leaving cortical cholinergic circuits unaffected. Changes in intracortical cortical excitability during sVNS, which were also observed in the control experiment with no stimulation were likely the effect of expectation related to participation in an interventional study.

• Jezik: Angleški jezik
• Ključne besede: neurology, neuroscience, transcutaneous auricular vagal nerve stimulation, short-interval intracortical inhibition, short-latency afferent inhibition, active motor threshold, resting motor threshold, short latency intracortical inhibition, vagal nerve stimulation
• Vrsta gradiva: Članek v reviji
• Tipologija: 1.01 - Izvirni znanstveni članek
• Organizacija: MF - Medicinska fakulteta ; FRI - Fakulteta za računalništvo in informatiko; FF - Filozofska fakulteta
• Status publikacije: Objavljeno
• Različica publikacije: Objavljena publikacija
• Leto izida: 2023
• Št. strani: Str. 2160-2173
• Številčenje: Vol. 57, no. 12
• PID: 20.500.12556/RUL-147467
• UDK: 616.8:004:
• ISSN pri članku: 1460-9568
• DOI: 10.1111/ejn.16004
• COBISS.SI-ID: 152114947
• Datum objave v RUL: 05.07.2023

Gradivo je del revije

• Naslov: European journal of neuroscience
• Skrajšan naslov: EJN, Eur. j. neurosci.
• Založnik: Wiley, Federation of European Neuroscience Societies
• ISSN: 1460-9568
• COBISS.SI-ID: 517706521

Licence

• Licenca: CC BY-NC-ND 4.0, Creative Commons Priznanje avtorstva-Nekomercialno-Brez predelav 4.0 Mednarodna
• Povezava: http://creativecommons.org/licenses/by-nc-nd/4.0/deed.sl
• Opis: Najbolj omejujoča licenca Creative Commons. Uporabniki lahko prenesejo in delijo delo v nekomercialne namene in ga ne smejo uporabiti za nobene druge namene.

Sekundarni jezik

• Jezik: Slovenski jezik
• Ključne besede: nevrologija, nevroznanost, transkutana aurikularna stimulacija vagalnega živca, kratkotrajna intrakortikalna inhibicija, kratkotrajna aferentna inhibicija

Projekti

• Financer: ARRS - Agencija za raziskovalno dejavnost Republike Slovenije

• Financer: Drugi - Drug financer ali več financerjev
• Program financ.: University Medical Centre Ljubljana