In our master's thesis, we synthesised and evaluated some new dexrazoxane analogues as potential inhibitors of human DNA topoisomerase II. For most of the proposed compounds, we wanted to make structural changes to the central propane-1,2-diyl that links the two piperazine-2,6-dione heterocycles in the dexrazoxane molecule. We wanted to prepare two compounds that have a pentyl group or a phenyl ring in the central part instead of a methyl group, but unfortunately the last step of the synthesis was not successful. However, we successfully prepared compound 11 containing piperazine-2,6-dione heterocycles instead of the two piperazine-2,6-dione heterocycles linked with a 1-oxoethane-1,2-diyl linker. We have physicochemically investigated all new compounds and confirmed their identity and purity.
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