Pathology of the placenta in singletons after assisted reproductive technology compared to singletons after spontaneous conception : a systematic review

Belak, Urška (author), Pinter, Bojana (author), Ban, Helena (author), Velikonja, Mojca (author), Korošec, Sara (author)

Background: We reviewed the literature comparing the pathological characteristics of singleton births conceived after assisted reproductive technology (ART) with those after spontaneous conception. Methods: We reviewed PubMed, EMBASE, Ovid MEDLINE, Google Scopus, Scholar, Cochrane Central Register of Controlled Trials and the Web of Science for the previous 10 years, up to November 2022. Results: Four eligible studies included 3445 placentas, 806 after ART (IVF/ICSI). Placentas after ART differed in frequency of retroplacental and marginal hematomas (p = 0.04), increased thickness (p = 0.02), higher overall occurrences of vascular and anatomical pathology (p < 0.001) and more frequent marginal (p = 0.001) and membranous (p = 0.02) umbilical cord insertion than placentas from non-ART pregnancies. Conclusion: Further research is needed to determine the extent to which these placental changes in ART pregnancies alter its function and pregnancy outcome.

• Language: English
• Keywords: placenta, pathology, assisted reproductive technology, embryo transfer, in vitro fertilization
• Work type: Article
• Typology: 1.02 - Review Article
• Organization: MF - Faculty of Medicine
• Publication status: Published
• Publication version: Version of Record
• Year: 2023
• Number of pages: Str. 438–449
• Numbering: Vol. 42, no. 3
• PID: 20.500.12556/RUL-146811
• UDC: 618.1
• ISSN on article: 1551-3823
• DOI: 10.1080/15513815.2022.2157228
• COBISS.SI-ID: 136684291
• Publication date in RUL: 14.06.2023

Record is a part of a journal

• Title: Fetal and pediatric pathology
• Publisher: Taylor & Francis
• ISSN: 1551-3823
• COBISS.SI-ID: 512767257

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