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Detection of physiological control inputs preload and afterload from intrinsic pump parameters in total artificial heart
ID
Kirn, Borut
(
Avtor
),
ID
Diedrich, Mario
(
Avtor
),
ID
Schmitz-Rode, Thomas
(
Avtor
),
ID
Steinseifer, Ulrich
(
Avtor
),
ID
Jansen, Sebastian V.
(
Avtor
)
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MD5: 5F02030B67539ED3C754AB0770BF715C
URL - Izvorni URL, za dostop obiščite
https://onlinelibrary.wiley.com/doi/10.1111/aor.14481
Galerija slik
Izvleček
Background: In the total artificial heart (TAH), the inputs to the physiological control unit, preload, and afterload, are detected from intrinsic pump parameters (e.g., motor current). Within this study, their detection techniques are developed, and their reliability in pre- and afterload prediction is mapped for a broad range of cardiovascular system states. Methods: We used ReinHeart TAH which is a fully implantable TAH with a plunger coil drive that is alternately emptying the left and right chambers. From the coil currents we first derived a force generated by the piston with respect to its position and then analyzed its pattern to detect (1) preload—chamber filling, found as piston position at begin ejection and (2) afterload—mean outflow pressures, determined as linearly calibrated average piston force during ejection. TAH is then integrated into a mock loop circulation (MLC) which is set to 135 different steady operating points varying in chamber filling (0%–100%, five steps), mean outflow pressures (system circulation: 60–90–120 mm Hg, pulmonary circulation: 15–30-45 mm Hg), and heart cycle duration (171–600 ms in seven non-equidistant steps). The detected preload and afterload are compared to MLC set values, and the errors are mapped. Results: Respectively for the left and right chambers, the preload was detectable in 134 and 118 operating points and the mean error was ±3% and ±2%. The afterload was detectable in 135 and 87 operating points and the mean error was 37% and 30% respectively for left and right circulation. The operational points that are further away from homeostatic equilibrium values generally yielded larger errors. The largest errors were observed for right circulation at long cycle duration, low afterload, and low filling. Conclusions: The study yields reliable preload estimation in a broad range of physiological states, particularly for left circulation. Detection of afterload needs further improvements. The study revealed a need for piston movement optimization within the ReinHeart TAH during the early phase of systole.
Jezik:
Angleški jezik
Ključne besede:
afterload
,
cardiovascular system
,
intrinsic parameters
,
physiological control
,
preload
,
total artificial heart
Vrsta gradiva:
Članek v reviji
Tipologija:
1.01 - Izvirni znanstveni članek
Organizacija:
MF - Medicinska fakulteta
Status publikacije:
Objavljeno
Različica publikacije:
Objavljena publikacija
Leto izida:
2023
Št. strani:
Str. 817-827
Številčenje:
Vol. 47, iss. 5
PID:
20.500.12556/RUL-146029
UDK:
616.1
ISSN pri članku:
0160-564X
DOI:
10.1111/aor.14481
COBISS.SI-ID:
133370371
Datum objave v RUL:
18.05.2023
Število ogledov:
581
Število prenosov:
80
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Objavi na:
Gradivo je del revije
Naslov:
Artificial organs
Skrajšan naslov:
Artif. organs
Založnik:
International Center for Artificial Organ and Transplantation, Wiley
ISSN:
0160-564X
COBISS.SI-ID:
25020672
Licence
Licenca:
CC BY-NC-ND 4.0, Creative Commons Priznanje avtorstva-Nekomercialno-Brez predelav 4.0 Mednarodna
Povezava:
http://creativecommons.org/licenses/by-nc-nd/4.0/deed.sl
Opis:
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