Water-soluble chitosan eases development of mucoadhesive buccal films and wafers for children

Korelc, Karin (avtor), Larsen, Bjarke Strøm (avtor), Gašperlin, Mirjana (avtor), Tho, Ingunn (avtor)

Oromucosal films and wafers are user-friendly solid dosage forms offering easy and convenient administration, as well as rapid or controlled drug delivery. The aim of this study was to develop prednisolone containing child-friendly chitosan-based mucoadhesive films and wafers with a prolonged residence time on the buccal mucosa. Four different chitosan types (different molecular weights, degree of deacetylation (DDA), pattern of deacetylation) were studied for films prepared by solvent-cast-evaporation and wafers by freeze-drying. Mucoadhesive properties correlated with swelling abilities and were dependent on the chitosan type, the solvent, and the preparation method. Mucoadhesive forces were higher for formulations containing chitosan with higher DDA and for wafers compared to films. The drug release was relatively fast, especially for films (approx. 90 % in 15 minutes) and steadier for wafers (90 % in 45–120 minutes). Permeability was evaluated using artificial membranes and HT29-MTX cell-monolayers. The developed formulations exhibited good biocompatibility. Organoleptic properties can be improved by choosing a homogenously deacetylated chitosan type that provides a more neutral pH. Using hydroxypropyl-beta-cyclodextrin-complexation for taste masking of bitter drugs also reduced wafers’ drug release rate. Mucoadhesive wafers are promising alternatives to films with a slower drug release rate and stronger mucoadhesion.

• Jezik: Angleški jezik
• Ključne besede: biocompatibility, HT29-MTX cells, organoleptic properties, patient-centric drug delivery, prednisolone, Viscosan
• Vrsta gradiva: Članek v reviji
• Tipologija: 1.01 - Izvirni znanstveni članek
• Organizacija: FFA - Fakulteta za farmacijo
• Status publikacije: Objavljeno
• Različica publikacije: Objavljena publikacija
• Leto izida: 2023
• Št. strani: 13 str.
• Številčenje: Vol. 631, art. 122544
• PID: 20.500.12556/RUL-145391
• UDK: 615.453
• ISSN pri članku: 0378-5173
• DOI: 10.1016/j.ijpharm.2022.122544
• COBISS.SI-ID: 149824515
• Datum objave v RUL: 20.04.2023

Gradivo je del revije

• Naslov: International journal of pharmaceutics
• Skrajšan naslov: Int. j. pharm.
• Založnik: Elsevier/North-Holland
• ISSN: 0378-5173
• COBISS.SI-ID: 3087631

Licence

• Licenca: CC BY-NC-ND 4.0, Creative Commons Priznanje avtorstva-Nekomercialno-Brez predelav 4.0 Mednarodna
• Povezava: http://creativecommons.org/licenses/by-nc-nd/4.0/deed.sl
• Opis: Najbolj omejujoča licenca Creative Commons. Uporabniki lahko prenesejo in delijo delo v nekomercialne namene in ga ne smejo uporabiti za nobene druge namene.

Sekundarni jezik

• Jezik: Slovenski jezik
• Ključne besede: dostava zdravil, biokompatibilnost, celice HT29-MTX, organoleptične lastnosti, prednizolon, Viscosan, zdravila, farmacevtske oblike

Projekti

• Financer: EC - European Commission
• Program financ.: Erasmus+