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Water-soluble chitosan eases development of mucoadhesive buccal films and wafers for children
ID Korelc, Karin (Author), ID Larsen, Bjarke Strøm (Author), ID Gašperlin, Mirjana (Author), ID Tho, Ingunn (Author)

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Abstract
Oromucosal films and wafers are user-friendly solid dosage forms offering easy and convenient administration, as well as rapid or controlled drug delivery. The aim of this study was to develop prednisolone containing child-friendly chitosan-based mucoadhesive films and wafers with a prolonged residence time on the buccal mucosa. Four different chitosan types (different molecular weights, degree of deacetylation (DDA), pattern of deacetylation) were studied for films prepared by solvent-cast-evaporation and wafers by freeze-drying. Mucoadhesive properties correlated with swelling abilities and were dependent on the chitosan type, the solvent, and the preparation method. Mucoadhesive forces were higher for formulations containing chitosan with higher DDA and for wafers compared to films. The drug release was relatively fast, especially for films (approx. 90 % in 15 minutes) and steadier for wafers (90 % in 45–120 minutes). Permeability was evaluated using artificial membranes and HT29-MTX cell-monolayers. The developed formulations exhibited good biocompatibility. Organoleptic properties can be improved by choosing a homogenously deacetylated chitosan type that provides a more neutral pH. Using hydroxypropyl-beta-cyclodextrin-complexation for taste masking of bitter drugs also reduced wafers’ drug release rate. Mucoadhesive wafers are promising alternatives to films with a slower drug release rate and stronger mucoadhesion.

Language:English
Keywords:biocompatibility, HT29-MTX cells, organoleptic properties, patient-centric drug delivery, prednisolone, Viscosan
Work type:Article
Typology:1.01 - Original Scientific Article
Organization:FFA - Faculty of Pharmacy
Publication status:Published
Publication version:Version of Record
Year:2023
Number of pages:13 str.
Numbering:Vol. 631, art. 122544
PID:20.500.12556/RUL-145391 This link opens in a new window
UDC:615.453
ISSN on article:0378-5173
DOI:10.1016/j.ijpharm.2022.122544 This link opens in a new window
COBISS.SI-ID:149824515 This link opens in a new window
Publication date in RUL:20.04.2023
Views:595
Downloads:111
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Record is a part of a journal

Title:International journal of pharmaceutics
Shortened title:Int. j. pharm.
Publisher:Elsevier
ISSN:0378-5173
COBISS.SI-ID:3087631 This link opens in a new window

Licences

License:CC BY-NC-ND 4.0, Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
Link:http://creativecommons.org/licenses/by-nc-nd/4.0/
Description:The most restrictive Creative Commons license. This only allows people to download and share the work for no commercial gain and for no other purposes.

Secondary language

Language:Slovenian
Keywords:dostava zdravil, biokompatibilnost, celice HT29-MTX, organoleptične lastnosti, prednizolon, Viscosan, zdravila, farmacevtske oblike

Projects

Funder:EC - European Commission
Funding programme:Erasmus+

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