Intra-species variations of bioactive compounds of two dictyota species from the Adriatic Sea : antioxidant, antimicrobial, dermatological, dietary, and neuroprotective potential

Martić, Ana (author), Čižmek, Lara (author), Ul'yanovskii, Nikolai (author), Paradžik, Tina (author), Perković, Lucija (author), Matijević, Gabrijela (author), Vujović, Tamara (author), Baković, Marija (author), Babić, Sanja (author), Kosyakov, Dmitry (author), Trebše, Polonca (author), Čož-Rakovac, Rozelindra (author)

The marine environment has a significant impact on life on Earth. Organisms residing in it are vital for the ecosystem but also serve as an inexhaustible source of biologically active compounds. Herein, the biodiversity of two brown seaweeds, Dictyota dichotoma and Dictyota fasciola from the Adriatic Sea, was evaluated. The aim of the study was the determination of differences in compound composition while comparing their activities, including antioxidant, antimicrobial, and enzyme inhibition, in connection to human digestion, dermatology, and neurological disorders. Chemical analysis revealed several terpenoids and steroids as dominant molecules, while fucoxanthin was the main identified pigment in both algae. D. dichotoma had higher protein, carbohydrate, and pigment content. Omega-6 and omega-3 fatty acids were identified, with the highest amount of dihomo-γ-linolenic acid and α-linolenic acid in D. dichotoma. Antimicrobial testing revealed a dose-dependent inhibitory activity of methanolic fraction against Escherichia coli and Staphylococcus aureus. Moderate antioxidant activity was observed for both algae fractions, while the dietary potential was high, especially for the D. fasciola dichloromethane fraction, with inhibition percentages of around 92% for α-amylase and 57% for pancreatic lipase at 0.25 mg/mL. These results suggest that Dictyota species might be a potent source of naturally derived agents for obesity and diabetes.

• Language: English
• Keywords: Dictyota dichotoma, Dictyota fasciola, brown seaweeds, chromatography, toxicity, proteins, carbohydrates, amino acids, bioactivity
• Work type: Article
• Typology: 1.01 - Original Scientific Article
• Organization: ZF - Faculty of Health Sciences
• Publication status: Published
• Publication version: Version of Record
• Publication date: 01.01.2023
• Year: 2023
• Number of pages: 30 str.
• Numbering: Vol. 12, iss. 4, art. 857
• PID: 20.500.12556/RUL-145158
• UDC: 543.544
• ISSN on article: 2076-3921
• DOI: 10.3390/antiox12040857
• COBISS.SI-ID: 148389635
• Publication date in RUL: 11.04.2023

Record is a part of a journal

• Title: Antioxidants
• Shortened title: Antioxidants
• Publisher: MDPI
• ISSN: 2076-3921
• COBISS.SI-ID: 522976025

Licences

• License: CC BY 4.0, Creative Commons Attribution 4.0 International
• Link: http://creativecommons.org/licenses/by/4.0/
• Description: This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.
• Licensing start date: 01.04.2023

Secondary language

• Language: Undetermined
• Keywords: Dictyota dichotoma, Dictyota fasciola, rjave morske alge, kromatografija, toksičnost, beljakovine, ogljikovi hidrati, aminokisline, bioaktivnost