Semaglutide delays 4-hour gastric emptying in women with polycystic ovary syndrome and obesity

Jensterle Sever, Mojca (author), Ferjan, Simona (author), Ležaič, Luka (author), Sočan, Aljaž (author), Goričar, Katja (author), Zaletel, Katja (author), Janež, Andrej (author)

Aim: To evaluate the effect of once-weekly subcutaneous semaglutide 1.0 mg on the late digestive period of gastric emptying (GE) after ingestion of a standardized solid test meal by using technetium scintigraphy, the reference method for this purpose. Methods: We conducted a single-blind, placebo-controlled trial in 20 obese women with polycystic ovary syndrome (PCOS; mean [range] age 35 [32.3-40.8] years, body mass index 37 [30.7-39.8] kg/m$^2$) randomized to subcutaneous semaglutide 1.0 mg once weekly or placebo for 12 weeks. GE was assessed after ingestion of [$^{99mT}$c] colloid in a pancake labelled with radiopharmaceutical by scintigraphy using sequential static imaging and dynamic acquisition at baseline and at Week 13. Estimation of GE was obtained by repeated imaging of remaining [$^{99mT}$c] activity at fixed time intervals over the course of 4 hours after ingestion. Results: From baseline to the study end, semaglutide increased the estimated retention of gastric contents by 3.5% at 1 hour, 25.5% at 2 hours, 38.0% at 3 hours and 30.0% at 4 hours after ingestion of the radioactively labelled solid meal. Four hours after ingestion, semaglutide retained 37% of solid meal in the stomach compared to no gastric retention in the placebo group (P = 0.002). Time taken for half the radiolabelled meal to empty from the stomach was significantly longer in the semaglutide group than the placebo group (171 vs. 118 min; P < 0.001). Conclusion: Semaglutide markedly delayed 4-hour GE in women with PCOS and obesity.

• Language: English
• Keywords: PCOS, obesity, semaglutide, gastric emptying, scintigraphy
• Work type: Article
• Typology: 1.01 - Original Scientific Article
• Organization: MF - Faculty of Medicine
• Publication status: Published
• Publication version: Version of Record
• Year: 2023
• Number of pages: Str. 975-984
• Numbering: Vol. 25, iss. 4
• PID: 20.500.12556/RUL-145004
• UDC: 616.4
• ISSN on article: 1462-8902
• DOI: 10.1111/dom.14944
• COBISS.SI-ID: 134184963
• Publication date in RUL: 29.03.2023

Record is a part of a journal

• Title: Diabetes, obesity and metabolism
• Shortened title: Diabetes obes. metab.
• Publisher: Wiley
• ISSN: 1462-8902
• COBISS.SI-ID: 13290713

Licences

• License: CC BY-NC-ND 4.0, Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
• Link: http://creativecommons.org/licenses/by-nc-nd/4.0/
• Description: The most restrictive Creative Commons license. This only allows people to download and share the work for no commercial gain and for no other purposes.

Secondary language

• Language: Slovenian
• Keywords: PCOS, debelost, semaglutid

Projects

• Funder: ARRS - Slovenian Research Agency
• Project number: P3-0343
• Name: Etiologija, zgodnje odkrivanje in zdravljenje bolezni pri otrocih in mladostnikih

• Funder: ARRS - Slovenian Research Agency
• Project number: P3-0298
• Name: Geni, hormonske in osebnostne spremembe pri metabolnih motnjah