Autologous platelet and extracellular vesicle-rich plasma as therapeutic fluid : a review

Troha, Kaja (avtor), Vozel, Domen (avtor), Arko, Matevž (avtor), Bedina Zavec, Apolonija (avtor), Dolinar, Drago (avtor), Hočevar, Matej (avtor), Jan, Zala (avtor), Kisovec, Matic (avtor), Kocjančič, Boštjan (avtor), Pađen, Ljubiša (avtor), Pajnič, Manca (avtor), Penič, Samo (avtor), Romolo, Anna (avtor), Repar, Neža (avtor), Spasovski, Vesna (avtor), Steiner, Nejc (avtor), Šuštar, Vid (avtor), Iglič, Aleš (avtor), Drobne, Damjana (avtor), Kogej, Ksenija (avtor), Battelino, Saba (avtor), Kralj-Iglič, Veronika (avtor)

The preparation of autologous platelet and extracellular vesicle-rich plasma (PVRP) has been explored in many medical fields with the aim to benefit from its healing potential. In parallel, efforts are being invested to understand the function and dynamics of PVRP that is complex in its composition and interactions. Some clinical evidence reveals beneficial effects of PVRP, while some report that there were no effects. To optimize the preparation methods, functions and mechanisms of PVRP, its constituents should be better understood. With the intention to promote further studies of autologous therapeutic PVRP, we performed a review on some topics regarding PVRP composition, harvesting, assessment and preservation, and also on clinical experience following PVRP application in humans and animals. Besides the acknowledged actions of platelets, leukocytes and different molecules, we focus on extracellular vesicles that were found abundant in PVRP.

• Jezik: Angleški jezik
• Ključne besede: platelet-rich plasma, platelets, centrifugation, extracellular vesicles, small cellular particles, wound healing, regeneration, fresh-frozen plasma, intercellular signaling peptides and proteins
• Vrsta gradiva: Članek v reviji
• Tipologija: 1.02 - Pregledni znanstveni članek
• Organizacija: ZF - Zdravstvena fakulteta ; MF - Medicinska fakulteta ; FE - Fakulteta za elektrotehniko; BF - Biotehniška fakulteta ; FKKT - Fakulteta za kemijo in kemijsko tehnologijo
• Status publikacije: Objavljeno
• Različica publikacije: Objavljena publikacija
• Datum objave: 08.02.2023
• Leto izida: 2023
• Št. strani: 39 str.
• Številčenje: Vol. 24, no. 4, art.3420
• PID: 20.500.12556/RUL-144471
• UDK: 577:616.15
• ISSN pri članku: 1422-0067
• DOI: 10.3390/ijms24043420
• COBISS.SI-ID: 142752771
• Datum objave v RUL: 23.02.2023

Gradivo je del revije

• Naslov: International journal of molecular sciences
• Skrajšan naslov: Int. j. mol. sci.
• Založnik: MDPI
• ISSN: 1422-0067
• COBISS.SI-ID: 2779162

Licence

• Licenca: CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
• Povezava: http://creativecommons.org/licenses/by/4.0/deed.sl
• Opis: To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.
• Začetek licenciranja: 08.02.2023

Sekundarni jezik

• Jezik: Ni določen
• Ključne besede: plazma, bogata s trombociti, trombociti, centrifugiranje, zunajcelični vezikli, majhni celični delci, celjenje ran, regeneracija, sveže zamrznjena plazma, medcelični signalni peptidi in proteini