Autologous platelet and extracellular vesicle-rich plasma as therapeutic fluid : a review

Troha, Kaja (author), Vozel, Domen (author), Arko, Matevž (author), Bedina Zavec, Apolonija (author), Dolinar, Drago (author), Hočevar, Matej (author), Jan, Zala (author), Kisovec, Matic (author), Kocjančič, Boštjan (author), Pađen, Ljubiša (author), Pajnič, Manca (author), Penič, Samo (author), Romolo, Anna (author), Repar, Neža (author), Spasovski, Vesna (author), Steiner, Nejc (author), Šuštar, Vid (author), Iglič, Aleš (author), Drobne, Damjana (author), Kogej, Ksenija (author), Battelino, Saba (author), Kralj-Iglič, Veronika (author)

The preparation of autologous platelet and extracellular vesicle-rich plasma (PVRP) has been explored in many medical fields with the aim to benefit from its healing potential. In parallel, efforts are being invested to understand the function and dynamics of PVRP that is complex in its composition and interactions. Some clinical evidence reveals beneficial effects of PVRP, while some report that there were no effects. To optimize the preparation methods, functions and mechanisms of PVRP, its constituents should be better understood. With the intention to promote further studies of autologous therapeutic PVRP, we performed a review on some topics regarding PVRP composition, harvesting, assessment and preservation, and also on clinical experience following PVRP application in humans and animals. Besides the acknowledged actions of platelets, leukocytes and different molecules, we focus on extracellular vesicles that were found abundant in PVRP.

• Language: English
• Keywords: platelet-rich plasma, platelets, centrifugation, extracellular vesicles, small cellular particles, wound healing, regeneration, fresh-frozen plasma, intercellular signaling peptides and proteins
• Work type: Article
• Typology: 1.02 - Review Article
• Organization: ZF - Faculty of Health Sciences; MF - Faculty of Medicine; FE - Faculty of Electrical Engineering; BF - Biotechnical Faculty; FKKT - Faculty of Chemistry and Chemical Technology
• Publication status: Published
• Publication version: Version of Record
• Publication date: 08.02.2023
• Year: 2023
• Number of pages: 39 str.
• Numbering: Vol. 24, no. 4, art.3420
• PID: 20.500.12556/RUL-144471
• UDC: 577:616.15
• ISSN on article: 1422-0067
• DOI: 10.3390/ijms24043420
• COBISS.SI-ID: 142752771
• Publication date in RUL: 23.02.2023

Record is a part of a journal

• Title: International journal of molecular sciences
• Shortened title: Int. j. mol. sci.
• Publisher: MDPI
• ISSN: 1422-0067
• COBISS.SI-ID: 2779162

Licences

• License: CC BY 4.0, Creative Commons Attribution 4.0 International
• Link: http://creativecommons.org/licenses/by/4.0/
• Description: This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.
• Licensing start date: 08.02.2023

Secondary language

• Language: Undetermined
• Keywords: plazma, bogata s trombociti, trombociti, centrifugiranje, zunajcelični vezikli, majhni celični delci, celjenje ran, regeneracija, sveže zamrznjena plazma, medcelični signalni peptidi in proteini