Optimization of brain tumours irradiation : determining the set-up margin

Žager Marciuš, Valerija (avtor), Dolenc, Laura (avtor), Smrdel, Uroš (avtor)

The aim of this work was to evaluate whether the excising margin of the clinical tumor volume and planning target volume correspond with calculated radiation margin based on systematic errors, and definition of radiation margins of individual brain lobes. This research was a retrospective cross-sectional study. We checked the systematic errors and calculated their average and the size of radiation margins. The average systematic errors were calculated in four directions: lateral, longitudinal, vertical, and rotation. The largest average systematic error was calculated in the lateral direction in the cerebellar area, and the error was also statistically significant (p < 0.05). In rotational direction we notice the statistically significant difference in frontal lobe (p = 0.037), and cerebellar area (p = 0.002). The largest safety margin, as measured by the average systematic errors, is required for irradiation of the cerebellum. The safety margin size of 6.94 mm was calculated according to the formula of Van Herk. However, the smallest safety margin can be used for irradiation of the occipital lobe of the brain, namely 4.85 mm. The linear regression results that only cerebellar lesions affect lateral displacements. Based on our calculation of the mean systematic errors, we estimate that the clinical target volume – planning target volume safety margin can't be reduced further from the current 5 mm to a size of 3 mm without the use of image guided radiotherapy.

• Jezik: Angleški jezik
• Ključne besede: brain tumor, geometric verification of radiation, modern radiation therapy technique, radiation treatment margin, radiotherapy
• Vrsta gradiva: Članek v reviji
• Tipologija: 1.01 - Izvirni znanstveni članek
• Organizacija: ZF - Zdravstvena fakulteta
• Status publikacije: Objavljeno
• Različica publikacije: Objavljena publikacija
• Datum objave: 01.01.2022
• Leto izida: 2022
• Št. strani: Str. 235-240
• Številčenje: Vol. 37, no. 3
• PID: 20.500.12556/RUL-144280
• UDK: 616-073:615.849
• ISSN pri članku: 1451-3994
• DOI: 10.2298/NTRP2203235Z
• COBISS.SI-ID: 141099523
• Datum objave v RUL: 09.02.2023

Gradivo je del revije

• Naslov: Nuclear Technology & Radiation Protection
• Skrajšan naslov: Nucl. Technol. Radiat. Prot.
• Založnik: Vinča Instituta of Nuclear Sciences
• ISSN: 1451-3994
• COBISS.SI-ID: 18296103

Licence

• Licenca: CC BY-NC-ND 3.0, Creative Commons Priznanje avtorstva-Nekomercialno-Brez predelav 3.0 Nedoločena
• Povezava: https://creativecommons.org/licenses/by-nc-nd/3.0/deed.sl
• Opis: Dovoljuje kopiranje in razširjanje vsebin v kakršnemkoli mediju in obliki. Primerno morate navesti avtorja, povezavo do licence in označiti spremembe, če so kakšne nastale. To lahko storite na kakršenkoli razumen način, vendar ne na način, ki bi namigoval na to, da dajalec licence podpira vas ali vašo uporabo dela. Te vsebine ne smete uporabiti v komercialne namene. Če vsebino predelate (remixate), uredite ali na njej gradite, spremenjene vsebine ne smete razširjati. Ne smete uporabiti pravnih določil ali tehničnih ukrepov, ki bi pravno omejili ali onemogočilo druge, da bi storili karkoli, kar licenca dovoli.
• Začetek licenciranja: 06.02.2023

Sekundarni jezik

• Jezik: Ni določen
• Ključne besede: možganski tumor, geometrijska verifikacija obsevanja, sodobna tehnika obsevanja, rob obsevanja, radioterapija