Assessment of Vitamin D status in Slovenian premenopausal and postmenopausal women, Using total, free, and bioavailable 25-hydroxyvitamin D (25(OH)D)

Vičič, Vid (avtor), Kukec, Andreja (avtor), Kugler, Saša (avtor), Geršak, Ksenija (avtor), Osredkar, Joško (avtor), Pandel Mikuš, Ruža (avtor)

The objective of our study was to evaluate vitamin D status and its predictors in Slovenian premenopausal and postmenopausal women. A cross-sectional study was carried out between 1 March 2021 and 31 May 2021. A total of 319 healthy women from the Central Slovenian region aged between 44 and 65 were recruited; 176 were included in the final analysis. The vitamin D status was determined by measuring the total 25-Hydroxycholecalciferol (25(OH)D) concentration, vitamin D binding protein (DBP), and albumin and calculating the bioavailable 25(OH)D and free 25(OH)D. For the calculation of bioavailable and free 25(OH)D, we developed a new online calculator. The Endocrine Society’s thresholds for vitamin D deficiency and insufficiency were used; 29.0% of premenopausal and 24.4% of postmenopausal subjects were found to be vitamin D deficient (total 25(OH)D < 50 nmol/L); 76.8% of the premenopausal and 61.7% of postmenopausal subjects were found to have insufficient levels (total 25(OH)D < 75 nmol/L). Premenopausal women had 11.8% lower total 25(OH)D, 32.2% lower bioavailable 25(OH)D, and 25.2% higher DBP than postmenopausal women. The most important predictors of vitamin D status were vitamin D supplementation and time spent in the sun. Contrary to similar studies, the vitamin D status in Slovenian postmenopausal women was significantly better than in premenopausal women. In postmenopausal women, the measurement of free or bioavailable 25(OH)D instead of the total 25(OH)D could be advantageous.

• Jezik: Angleški jezik
• Ključne besede: 25(OH)D, postmenopausal, premenopausal, bioavailable 25(OH)D, free 25(OH)D, online calculator, cholecalciferol, calcidiol, menopause, DBP
• Vrsta gradiva: Članek v reviji
• Tipologija: 1.01 - Izvirni znanstveni članek
• Organizacija: FFA - Fakulteta za farmacijo ; ZF - Zdravstvena fakulteta ; MF - Medicinska fakulteta
• Status publikacije: Objavljeno
• Različica publikacije: Objavljena publikacija
• Leto izida: 2022
• Št. strani: 12 str.
• Številčenje: Vol. 14, iss. 24, art. 5349
• PID: 20.500.12556/RUL-143358
• UDK: 577.161.2:618.173
• ISSN pri članku: 2072-6643
• COBISS.SI-ID: 134262787
• Datum objave v RUL: 16.12.2022

Gradivo je del revije

• Naslov: Nutrients
• Skrajšan naslov: Nutrients
• Založnik: MDPI
• ISSN: 2072-6643
• COBISS.SI-ID: 2948140

Licence

• Licenca: CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
• Povezava: http://creativecommons.org/licenses/by/4.0/deed.sl
• Opis: To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.

Sekundarni jezik

• Jezik: Slovenski jezik
• Ključne besede: po menopavzi, pred menopavzo, biorazpoložljiv 25(OH)D, prosti 25(OH)D, spletni kalkulator, holekalciferol, kalcidiol

Projekti

• Financer: ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
• Številka projekta: P3-0360-2019
• Naslov: Celostna obravnava alergijskih bolezni in astme v Sloveniji: od epidemiologije do genetike

• Financer: ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
• Številka projekta: P3-0124-2020
• Naslov: Metabolni in prirojeni dejavniki reproduktivnega zdravja, porod III