Sistematični pregled vpliva resveratrola na potek sladkorne bolezni tipa 2

Vodolšak, Tanja (author), Mravljak, Janez (mentor)

Ozadje: Sladkorna bolezen predstavlja velik zdravstveni problem v današnjem svetu. Obstajata dve obliki sladkorne bolezni, tip 1 in tip 2, pri čemer je tip 2 bolj pogost. Pojavnost sladkorne bolezni tipa 2 (SB2) je večja pri osebah s prekomerno telesno težo ali debelih ter se povečuje s starostjo, vendar danes zaradi neustreznega življenjskega sloga vse več otrok in mladostnikov zboli za SB2. Sladkorna bolezen lahko povzroči resne posledice, ki povzročajo poškodbe številnih telesnih organov in tkiv. Zaradi tega raziskovalci skušajo razviti alternativne prehranske dodatke rastlinskega izvora, kot je fitoaleksin resveratrol, ki bi dopolnjevali obstoječa terapevtska zdravila za preprečevanje in zdravljenje SB2. Namen dela: Namen izdelave magistrske naloge je sistematično pregledati in preučiti vpliv dodatka resveratrola na diabetične parametre pri odraslih ljudeh s SB2 ter oceniti, ali je smiselno uporabljati resveratrol kot prehranski dodatek pri sladkorni bolezni tipa 2. Metode: S pomočjo vnaprej določenih iskalnih nizov smo poiskali raziskave v podatkovnih bazah Web of Science, PubMed in Google Učenjak. Pri izbiri najprimernejših člankov smo sledili smernicam PRISMA ter se omejili samo na članke, ki so objavljeni v angleškem jeziku. Vključili smo raziskave, ki so poročale o vsaj enem od izbranih diabetičnih parametrov. Rezultati: V sistematični pregled smo vključili 16 raziskav, ki so ustrezale vključitvenim dejavnikom ter 13 raziskav, ki smo jih izbrali naključno. Najprej smo jih analizirali glede na leto objave, potem glede na državo, v kateri je bila raziskava izvedena, ter glede na načrt raziskave. Nato smo v dveh preglednicah predstavili glavne značilnosti vsake raziskave. Razdelili smo jih glede na spol, glede na pripravek resveratrola pri diabetikih in ne-diabetikih ter glede na zdravstveno stanje udeležencev. Večina raziskav je poročala o pozitivnem učinku resveratrola pri nadzoru glikemije in izboljšanju inzulinske rezistence in občutljivosti na inzulin, medtem ko nekatere raziskave opisujejo nepomemben vpliv resveratrola na diabetične parametre. Večina preiskovancev vključenih v raziskave je resveratrol dobro prenašala, o hujših neželenih učinkih pa ne poročajo. Sklep: Rezultati raziskav poročajo, da je resveratrol lahko možna izbira pri zdravljenju sladkorne bolezni, zniževanju inzulinske rezistence in izboljšanju diabetičnih parametrov, vendar je za potrditev teh ugotovitev treba narediti več visokokakovostnih randomiziranih kliničnih raziskav z večjim številom preiskovancev in daljšim časom intervencije.

• Language: Slovenian
• Keywords: resveratrol, trans-resveratrol, sladkorna bolezen tipa 2, inzulinska rezistenca in občutljivost na inzulin
• Work type: Master's thesis/paper
• Organization: FFA - Faculty of Pharmacy
• Year: 2022
• PID: 20.500.12556/RUL-143273
• Publication date in RUL: 11.12.2022

Secondary language

• Language: English
• Title: Systematic review of the influence of resveratrol on the course of type 2 diabetes

Abstract

Background: Diabetes mellitus is a major health problem in today's world. There are two forms of diabetes, type 1 and type 2, with type 2 being more common. The incidence of type 2 diabetes (SB2) is higher in overweight or obese people and increases with age, but today more and more children and adolescents are developing SB2 due to inadequate lifestyle choices. Diabetes can have serious consequences, causing damage to many organs and tissues of the body. For this reason, researchers are trying to develop alternative herbal dietary supplements, such as phytoalexin resveratrol, to complement existing therapeutic drugs for the prevention and treatment of SB2. Aim: The aim of this master's thesis is to systematically review and investigate the effect of resveratrol supplementation on diabetic parameters in adults with SB2 and to assess whether it is reasonable to use resveratrol as a dietary supplement in type 2 diabetes. Methods: We searched the Web of Science, PubMed and Google Scholar databases for research using predefined search strings. We followed PRISMA guidelines to select the most relevant articles and limited ourselves to articles published in English. We included studies that reported on at least one of the selected diabetic parameters. Results: We included 16 studies that met the inclusion factors in our systematic review and 13 studies that were randomly selected. We first analysed them according to the year of publication, then according to the country in which the survey was conducted, and then according to the survey design. We then present the main characteristics of each survey in two tables. They were divided according to sex, according to the use of resveratrol in diabetics and non-diabetics, and according to the health status of the participants. Most studies reported a positive effect of resveratrol in glycaemic control and improvement of insulin resistance and insulin sensitivity, while some studies described a non-significant effect of resveratrol on diabetic parameters. Most of the subjects included in the studies tolerated resveratrol well and no serious side effects were reported. Conclusion: Research results report that resveratrol may be a potential choice for treating diabetes, lowering insulin resistance and improving diabetic parameters, but more high-quality randomised clinical trials with larger numbers of subjects and longer intervention times are needed to confirm these findings.

• Keywords: resveratrol, trans-resveratrol, type 2 diabetes, insulin resistance and insulin sensitivity