Halogenated organic compounds are already a well–studied field of organic chemistry, yet their versatile use in everyday life still encourages us to create either new compound and materials or improve (more environmentally friendly) synthetic routes for their preparation. Organofluorine compounds are used, for example, in pharmaceuticals; as surfactants and as preservatives in agriculture; and inorganic fluorinated compounds can be found in Li–ion batteries and fuel cells. Perfluoroalkyl sulfides are an important type of these compounds, the key property of which is their lipophilicity. Due to its electronegativity and size, the fluorine atom can significantly affect the properties of organic molecules, chemical reactivity and it has very important role in biological activity. In this master's thesis I focused on the conversions of substituted thiols with various halogenated compounds. I used fluorinated and perfluorinated alkyl halides as reagents. Most of the reactions proved to be generally successful, but some reaction conditions had to be optimised. I prepared eighteen fluorinated sulfides and thirteen perfluorinated sulfides.
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