Patch testing with the European baseline series and 10 added allergens : single-centre study of 748 patients

Bizjak, Mojca (author), Adamič, Katja (author), Bajrović, Nisera (author), Eržen, Renato (author), Jošt, Maja (author), Kopač, Peter (author), Košnik, Mitja (author), Lalek, Nika (author), Zidarn, Mihaela (author), Dinevski, Dejan (author)

Background: The European baseline series (EBS) of contact allergens is subject to change. An allergen is considered for inclusion when routine patch testing of patients with suspected contact dermatitis results in ≥0.5% prevalence rate. Objectives: We aimed to determine the frequency of sensitizations to 30 EBS allergens and 10 locally added allergens. Additionally, we assessed the strength and evolution of reactions to all tested allergens and co-reactivity of additional allergens. Methods: Patch testing with our baseline series of 40 allergens was done in 748 consecutive adults. Tests were applied to the upper back and removed by patients after 48 h. Readings were done on Day 3 (D3) and D6 or D7 (D6/7). Positive reactions fulfilled the criteria of at least one plus (+) reaction. A retrospective analysis was done. Results: Eight allergens not listed in the EBS had ≥0.5% prevalence rate (i.e., cocamidopropyl betaine, thiomersal, disperse blue mix 106/124, 2-bromo-2-nitropropane-1, 3-diol, diazolidinyl urea, propylene glycol, Compositae mix II and dexamethasone-21-phosphate), and 16.6% of positive reactions would have been missed without D6/7 readings. Conclusion: We propose further studies to evaluate whether cocamidopropyl betaine, disperse blue mix 106/124, 2-bromo-2-nitropropane-1,3-diol, diazolidinyl urea and Compositae mix II need to be added to the EBS.

• Language: English
• Keywords: clinical epidemiology, baseline series, contact sensitization, patch tests, simultaneous reactivity, allergy and immunology, diagnosis, hypersensitivity, skin tests
• Work type: Article
• Typology: 1.01 - Original Scientific Article
• Organization: MF - Faculty of Medicine
• Publication status: Published
• Publication version: Version of Record
• Year: 2022
• Number of pages: Str. 439–446
• Numbering: Vol. 87, iss. 5
• PID: 20.500.12556/RUL-141976
• UDC: 616-097
• ISSN on article: 1600-0536
• DOI: 10.1111/cod.14178
• COBISS.SI-ID: 112721411
• Publication date in RUL: 13.10.2022

Record is a part of a journal

• Title: Contact dermatitis
• Publisher: Wiley
• ISSN: 1600-0536
• COBISS.SI-ID: 517686809

Licences

• License: CC BY-NC-ND 4.0, Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
• Link: http://creativecommons.org/licenses/by-nc-nd/4.0/
• Description: The most restrictive Creative Commons license. This only allows people to download and share the work for no commercial gain and for no other purposes.

Secondary language

• Language: Slovenian
• Keywords: klinična epidemiologija, osnovna serija, kontaktna senzibilizacija, kožni testi z obliži, sočasna reaktivnost, alergija in imunologija, diagnostika, preobčutljivost, kožni testi