Introduction: Biocompatibility of dental materials describes the compatibility of dental materials with tissue in the oral cavity and depends on the type of material, its location in the human body, and the expected function of the material. Biocompatible material does not elicit an immune response from the host. Today, the need for biocompatible materials is crucial because the materials must meet the appropriate mechanical, chemical, biological, and aesthetic requirements. Before new materials can be sold on the market, they must be sent through a series of different tests to determine biocompatibility with the host. They must be accompanied by safety data sheets containing information on the hazards of the material, first aid measures, and protection. Common diseases affecting laboratory technicians are contact dermatitis, asthma, pneumoconiosis, and silicosis. Common side effects that occur in patients include bronchitis, headaches, fatigue, burning mouth, swelling, and pain. Purpose: The purpose of this diploma work is to determine how different dental materials affect laboratory technicians during material handling, what the consequences of unprotected handling are, and how side effects can be prevented. At the same time, we want to find out how the same dental materials affect patients after inserting dental materials into the oral cavity. Methods: In this diploma work, we used the descriptive method of work where we reviewed domestic and foreign literature on checking the biocompatibility of dental materials, their side effects on patients and laboratory technicians, and how to protect themselves during handling the materials. At the same time, we also reviewed the literature on CAD/CAM technology. We used online databases Google Scholar, ScienceDirect, PubMed, and ResearchGate. The keywords used during the literature search are biocompatibility of dental materials, side effects, patient, laboratory technician, and occupational exposure. In the practical part of the thesis, we made two Co-Cr alloy bridges from steel and porcelain made by analog and digital methods and compared the risks that threaten the laboratory technician during the manufacture of products. Results: We made two Co-Cr alloy and porcelain bridges by analog and digital methods. Discussion and conclusion: The use of biocompatible dental materials is of vital importance. However, that does not mean dental materials are not harmful to the patients and laboratory technicians. Dental materials can cause side effects that require the replacement of dental material in patients and the use of protective equipment in laboratory technicians.
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