Poskusi povečanja topnosti izbranih fenantrolinskih ligandov

Bertoncelj, Urh (author), Turel, Iztok (mentor)

Namen diplomske naloge je bil poiskati način, kako bi povečal topnost substituiranemu fenantrolinskemu ligandu, konkretno 1,4-dihidrofenantrolin-4-on-3-karboksilni kislini (1,4-DPCA). Ta se ponaša z zelo koristno vlogo v regeneracijski medicini, vendar je zaradi nizke topnosti v vodi manj primeren za uporabo. V okviru diplomskega dela sem sintetiziral 1,4-DPCA in se odločil za povečevanje topnosti le-tega s pomočjo ionskih tekočin, bolj natančno z amonijevimi in fosfonijevimi hidroksidi. Pripravil sem ionsko spojino 1,4-DPCA s tetrabutilamonijevim hidroksidom, jo okarakteriziral in poiskal mejo topnosti v vodi s pomočjo umeritvene krivulje.

• Language: Slovenian
• Keywords: topnost, ionska tekočina, 1, 4-DPCA
• Work type: Bachelor thesis/paper
• Typology: 2.11 - Undergraduate Thesis
• Organization: FKKT - Faculty of Chemistry and Chemical Technology
• Year: 2022
• PID: 20.500.12556/RUL-139705
• COBISS.SI-ID: 126473219
• Publication date in RUL: 06.09.2022

Secondary language

• Language: English
• Title: Attempts to increase solubility of selected phenanthroline ligands

Abstract

The purpose of my thesis was finding a way to increase solubility of a substituted phenanthroline ligand 1,4-dihydrophenanthroline-4-one-3-carboxylic acid (1,4-DPCA). The substance has a useful role in regenerative medicine, but unfortunately it is still underused because of its' low solubility in water. 1,4-DPCA was synthesized and tested for increased solubility in different ionic liquids, especially in ammonium and phosphonium hydroxides. Ionic compound of 1,4-DPCA was prepared with tetrabutylammonium hydroxide, characterised and its' solubility limit determined using a calibration curve.

• Keywords: solubility, ionic liquid, 1, 4-DPCA