Cell models for Alzheimer’s and Parkinson’s disease : at the interface of biology and drug discovery

Cetin, Sandra (avtor), Knez, Damijan (avtor), Gobec, Stanislav (avtor), Kos, Janko (avtor), Pišlar, Anja (avtor)

Neurodegenerative diseases are severely debilitating conditions characterized primarily by progressive neuronal loss and impairment of the nervous system. Alzheimer’s and Parkinson’s diseases are the most common neurodegenerative disorders, and their impact is increasing as average life expectancy increases worldwide. Although the underlying mechanisms of both progressive diseases have been extensively studied, we still lack a comprehensive understanding of the molecular basis of both diseases. Current therapeutic options do not slow the progression of the diseases and only provide symptom relief. Cell models that resemble the characteristics of the disease in question are important in drug discovery projects because they provide information about the therapeutic benefits of drugs under development. Here, we review current in vitro cell models used to study the molecular basis of Alzheimer’s and Parkinson’s disease focusing on their potential for discovering of disease-modifying therapeutics to combat neurodegenerative diseases. We discuss phenotypic screening as an important approach for identifying novel therapeutic molecules. Advances in the development of cell-based assays for drug discovery are discussed, ranging from simple monoculture cell models to high-throughput three-dimensional cell models. Finally, we critically present the limitations of cell models and the caveats encountered in drug discovery to find effective treatment for neurodegenerative diseases.

• Jezik: Angleški jezik
• Ključne besede: neurodegenerative diseases, cell models, cytotoxicity assays, drug discovery, drug screening
• Vrsta gradiva: Članek v reviji
• Tipologija: 1.02 - Pregledni znanstveni članek
• Organizacija: FFA - Fakulteta za farmacijo
• Status publikacije: Objavljeno
• Različica publikacije: Objavljena publikacija
• Leto izida: 2022
• Št. strani: 11 str.
• Številčenje: Vol. 149, art. 112924
• PID: 20.500.12556/RUL-139099
• UDK: 615.4:54:616.831-003.8
• ISSN pri članku: 1950-6007
• DOI: 10.1016/j.biopha.2022.112924
• COBISS.SI-ID: 105487619
• Datum objave v RUL: 30.08.2022

Gradivo je del revije

• Naslov: Biomedicine & pharmacotherapy
• Založnik: Elsevier
• ISSN: 1950-6007
• COBISS.SI-ID: 23136261

Licence

• Licenca: CC BY-NC-ND 4.0, Creative Commons Priznanje avtorstva-Nekomercialno-Brez predelav 4.0 Mednarodna
• Povezava: http://creativecommons.org/licenses/by-nc-nd/4.0/deed.sl
• Opis: Najbolj omejujoča licenca Creative Commons. Uporabniki lahko prenesejo in delijo delo v nekomercialne namene in ga ne smejo uporabiti za nobene druge namene.

Sekundarni jezik

• Jezik: Slovenski jezik
• Ključne besede: nevrodegenerativne bolezni, celični modeli, preskusi citotoksičnosti, odkrivanje zdravil, Alzheimerjeva bolezen, Parkinsonova bolezen, farmacevtska kemija