In diploma work, I dealt with the synthesis of compounds, pyrazole derivatives, which have already been studied as potential antimalarials. I prepared the compounds according to the procedure from the literature. I successfully prepared methyl malonate hydrazide derivates from methyl malonyl chloride and hydrazine derivatives, which was confirmed by IR and NMR spectroscopy. In the second step, I condensed the obtained hydrazides with amide acetal and then cyclized them into pyrazoles. Using IR and NMR spectroscopy, I proved that I had successfully synthesized the desired products. We tested the biological activity of the products with standardized enzyme tests, which unfortunately showed that the compounds did not have the expected inhibitory effect on the PfDHODH enzyme.
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