Experimental exposure to bisphenol A has minimal effects on bone tissue in growing rams : a preliminary study

Brankovič, Jana (avtor), Leskovec, Jakob (avtor), Šturm, Sabina (avtor), Cerkvenik, Vesna (avtor), Šterpin, Saša (avtor), Osredkar, Joško (avtor), Pogorevc, Estera (avtor), Antolinc, David (avtor), Vrecl, Milka (avtor)

Bisphenol A (BPA) is a well-known synthetic compound that belongs to the group of endocrine-disrupting chemicals. Although bone tissue is a target for these compounds, studies on BPA-related effects on bone morphology in farm animals are limited. In this preliminary study, we investigated the effects of short-term dietary BPA exposure on femoral morphology, metabolism, mineral content, and biomechanical behavior in rams aged 9–12 months. Fourteen rams of the Istrian Pramenka breed were randomly divided into a BPA group and a control group (seven rams/group) and exposed to 25 μg BPA/kg bw for 64 days in feed. Blood was collected for determination of bone turnover markers (procollagen N-terminal propeptide, C-terminal telopeptide), and femurs were assessed via computed tomography, histomorphometry, three-point bending test, and mineral analysis. BPA had no significant effects on most of the parameters studied. Only mineral analysis showed decreased manganese (50%; p ≤ 0.05) and increased copper content (25%; p ≤ 0.05) in the femurs of BPA-exposed rams. These results suggest that a 2-month, low-dose exposure to BPA in growing rams did not affect the histomorphology, metabolism, and biomechanical behavior of femurs; however, it affected the composition of microelements, which could affect the histometric and biophysical properties of bone in the long term.

• Jezik: Angleški jezik
• Ključne besede: bisphenol A, rams, serum bone biomarkers, bone geometry, trabecular bone, cortical bone, bone biomechanics, mineral content
• Tipologija: 1.01 - Izvirni znanstveni članek
• Organizacija: VF - Veterinarska fakulteta ; BF - Biotehniška fakulteta ; FFA - Fakulteta za farmacijo ; FGG - Fakulteta za gradbeništvo in geodezijo
• Status publikacije: Objavljeno
• Različica publikacije: Objavljena publikacija
• Datum objave: 25.08.2022
• Leto izida: 2022
• Št. strani: 15 str.
• Številčenje: Vol. 12, no. 17, art. 2179
• PID: 20.500.12556/RUL-138935
• UDK: 636.09:615.9
• ISSN pri članku: 2076-2615
• DOI: 10.3390/ani12172179
• COBISS.SI-ID: 119202307
• Datum objave v RUL: 26.08.2022

Gradivo je del revije

• Naslov: Animals
• Skrajšan naslov: Animals
• Založnik: MDPI AG
• ISSN: 2076-2615
• COBISS.SI-ID: 519120409

Licence

• Licenca: CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
• Povezava: http://creativecommons.org/licenses/by/4.0/deed.sl
• Opis: To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.
• Začetek licenciranja: 25.08.2022