Cytoskeletal proteins as glioblastoma biomarkers and targets for therapy : a systematic review

Zottel, Alja (avtor), Jovchevska, Ivana (avtor), Šamec, Neja (avtor), Komel, Radovan (avtor)

Glioblastoma, the most common primary brain malignancy, is an exceptionally fatal cancer. Lack of suitable biomarkers and efficient treatment largely contribute to the therapy failure. Cytoskeletal proteins are crucial proteins in glioblastoma pathogenesis and can potentially serve as biomarkers and therapeutic targets. Among them, GFAP, has gained most attention as potential diagnostic biomarker, while vimentin and microtubules are considered as prospective therapeutic targets. Microtubules represent one of the best anti-cancer targets due to their critical role in cell proliferation. Despite testing in clinical trials, the efficiency of taxanes, epothilones, vinca-domain binding drugs, colchicine-domain binding drugs and γ-tubulin binding drugs remains to be confirmed. Moreover, tumor treating field that disrupts microtubules draw attention because of its high efficiency and is called “the fourth cancer treatment modality”. Thereby, because of the involvement of cytoskeleton in key physiological and pathological processes, its therapeutic potential in glioblastoma is currently extensively investigated.

• Jezik: Angleški jezik
• Ključne besede: cytoskeleton, glioblastoma, biomarkers, glioblastoma therapy, vimentin, microtubules
• Vrsta gradiva: Članek v reviji
• Tipologija: 1.02 - Pregledni znanstveni članek
• Organizacija: MF - Medicinska fakulteta
• Status publikacije: Objavljeno
• Različica publikacije: Objavljena publikacija
• Leto izida: 2021
• Št. strani: 13 str.
• Številčenje: Vol. 160, art. 103283
• PID: 20.500.12556/RUL-138698
• UDK: 616-006
• ISSN pri članku: 1879-0461
• DOI: 10.1016/j.critrevonc.2021.103283
• COBISS.SI-ID: 54458627
• Datum objave v RUL: 09.08.2022

Gradivo je del revije

• Naslov: Critical reviews in oncology/hematology
• Založnik: Elsevier
• ISSN: 1879-0461
• COBISS.SI-ID: 23222789

Licence

• Licenca: CC BY-NC-ND 4.0, Creative Commons Priznanje avtorstva-Nekomercialno-Brez predelav 4.0 Mednarodna
• Povezava: http://creativecommons.org/licenses/by-nc-nd/4.0/deed.sl
• Opis: Najbolj omejujoča licenca Creative Commons. Uporabniki lahko prenesejo in delijo delo v nekomercialne namene in ga ne smejo uporabiti za nobene druge namene.

Sekundarni jezik

• Jezik: Slovenski jezik
• Ključne besede: citoskelet, glioblastom, označevalci