Cytoskeletal proteins as glioblastoma biomarkers and targets for therapy : a systematic review

Zottel, Alja (author), Jovchevska, Ivana (author), Šamec, Neja (author), Komel, Radovan (author)

Glioblastoma, the most common primary brain malignancy, is an exceptionally fatal cancer. Lack of suitable biomarkers and efficient treatment largely contribute to the therapy failure. Cytoskeletal proteins are crucial proteins in glioblastoma pathogenesis and can potentially serve as biomarkers and therapeutic targets. Among them, GFAP, has gained most attention as potential diagnostic biomarker, while vimentin and microtubules are considered as prospective therapeutic targets. Microtubules represent one of the best anti-cancer targets due to their critical role in cell proliferation. Despite testing in clinical trials, the efficiency of taxanes, epothilones, vinca-domain binding drugs, colchicine-domain binding drugs and γ-tubulin binding drugs remains to be confirmed. Moreover, tumor treating field that disrupts microtubules draw attention because of its high efficiency and is called “the fourth cancer treatment modality”. Thereby, because of the involvement of cytoskeleton in key physiological and pathological processes, its therapeutic potential in glioblastoma is currently extensively investigated.

• Language: English
• Keywords: cytoskeleton, glioblastoma, biomarkers, glioblastoma therapy, vimentin, microtubules
• Work type: Article
• Typology: 1.02 - Review Article
• Organization: MF - Faculty of Medicine
• Publication status: Published
• Publication version: Version of Record
• Year: 2021
• Number of pages: 13 str.
• Numbering: Vol. 160, art. 103283
• PID: 20.500.12556/RUL-138698
• UDC: 616-006
• ISSN on article: 1879-0461
• DOI: 10.1016/j.critrevonc.2021.103283
• COBISS.SI-ID: 54458627
• Publication date in RUL: 09.08.2022

Record is a part of a journal

• Title: Critical reviews in oncology/hematology
• Publisher: Elsevier
• ISSN: 1879-0461
• COBISS.SI-ID: 23222789

Licences

• License: CC BY-NC-ND 4.0, Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
• Link: http://creativecommons.org/licenses/by-nc-nd/4.0/
• Description: The most restrictive Creative Commons license. This only allows people to download and share the work for no commercial gain and for no other purposes.

Secondary language

• Language: Slovenian
• Keywords: citoskelet, glioblastom, označevalci