Določitev polimorfizma farmacevtskih učinkovin z metodami termične analize

Cugelj, Andreja (author), Čelan Korošin, Nataša (mentor)

Razvoj farmacevtskega izdelka je lahko, zaradi različnih dejavnikov, zelo dolg, naporen in drag proces. Zelo pomemben med njimi je pojav polimorfizma. To je pojav, ko ima trdna kemijska spojina več različnih kristalnih struktur, oziroma lahko kristalizira na različne načine. Različni polimorfi iste spojine se v trdnem stanju obnašajo drugače in imajo drugačne kemijske in fizikalne lastnosti ter s tem drugačno biološko aktivnost in učinkovitost, zato je zelo pomembno, katero kristalno obliko snovi se uporabi za določen izdelek. Za določanje polimorfizma obstaja več različnih metod. V svojem diplomskem delu sem se osredotočila na metode termične analize, predvsem na termogravimetrično analizo (TGA) in diferenčno dinamično kalorimetrijo (DSC). Izbrala sem si dva vzorca, acetilsalicilno kislino in karbamazepin. Najprej sem v literaturi poiskala temperature tališč vseh kristalnih oblik snovi, potem pa sem za oba vzorca najprej izvedla termogravimetrično analizo, nato pa še diferenčno dinamično kalorimetrijo. Na koncu sem izvedla še infrardečo (IR) spektroskopijo obeh vzorcev.

• Language: Slovenian
• Keywords: polimorfizem, acetilsalicilna kislina, karbamazepin, termična analiza, termogravimetrična analiza (TGA) in diferenčna dinamična kalorimetrija (DSC)
• Work type: Bachelor thesis/paper
• Typology: 2.11 - Undergraduate Thesis
• Organization: FKKT - Faculty of Chemistry and Chemical Technology
• Year: 2022
• PID: 20.500.12556/RUL-137859
• COBISS.SI-ID: 116164355
• Publication date in RUL: 04.07.2022

CUGELJ, Andreja, 2022, Določitev polimorfizma farmacevtskih učinkovin z metodami termične analize [online]. Bachelor’s thesis. [Accessed 4 April 2025]. Retrieved from: https://repozitorij.uni-lj.si/IzpisGradiva.php?lang=eng&id=137859

Secondary language

• Language: English
• Title: Determination of polymorphism of active pharmaceutical ingredients by thermal analysis methods

Abstract

The development of a pharmaceutical product can be a very long, tedious and expensive process due to several factors. One very important factor is the phenomenon of polymorphism. This is a phenomenon where a solid chemical compound has several different crystal structures or can crystallize in different ways. Different polymorphs of the same compound behave differently in the solid state and have different chemical and physical properties, and therefore different biological activity and efficacy, so it is very important which crystalline form of the substance is used for a particular product. There are several different methods to determine the polymorphism. In my thesis, I focused on thermal analysis methods, mainly thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC). I chose two samples, acetylsalicylic acid and carbamazepine. First, I searched the literature for the melting points of all crystalline forms of the substance and then carried out thermogravimetric analysis and then differential dynamic calorimetry on both samples. Finally, I performed infrared spectroscopy (IR) on both samples.

• Keywords: polymorphism, acetylsalicylic acid, carbamazepine, thermal analysis, thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC)