Silicon dioxide is a widely used excipient in pharmacy, most often as an additive to powder mixtures for better flow properties. As a carrier of active substances for the production of solid dispersions of poorly water-soluble active substances, it has so far been studied only in the field of research, where the researchers usually do not produce the final pharmaceutical form, capsule or tablet. In the Master's thesis, we produced granules of silicon dioxide with different excipients using the method of a high-shear granulator in order to improve the compressibility of particles. We used six different commercially available mesoporous silicon dioxides (Syloid AL-1FP, Syloid XDP 3050, Aeroperl, Syloid 72FP, Syloid 3150, Syloid 244) with which we can produce solid dispersions of poorly water-soluble active substances. The granules were made using eleven different binding agents (Sugars or polyols: Lactose, Isomalt, Maltitol, Mannitol, Xylitol. Polymers: PVP K25, Avicel PH101, Vivapur 102, Hydroxypropyl cellulose, PVP F90, Eudragit EPO). We measured flow time, Carr’s index, Hausner ratio, loss of mass on drying, and particle size distribution and compressibility of the tablets. Based on the results of these analyses and properties of the produced tablets, we established which ratio of silicon dioxide to the individual excipient is the most optimal. The granules were tableted and we selected the most appropriate one for each group of excipients (polymers and polyols or sugars). The most optimal ratio of silicon dioxide to binding agent from both groups was 2:1. This ratio produced tablets with the best properties. From the group of polymers, the best binder was PVP K25 and from the group of sugars or polyols was Isomalt. We also measured the disintegration time of the final product. All tablets disintegrated in less than 3 minutes so they meet the definition of orodispersible tablets.
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