Causation of oxidative stress and defense response of a yeast cell model after treatment with orthodontic alloys consisting of metal ions

Kovač, Vito (avtor), Bergant, Matic (avtor), Ščančar, Janez (avtor), Primožič, Jasmina (avtor), Jamnik, Polona (avtor), Poljšak, Borut (avtor)

Misaligned teeth have a tremendous impact on oral and dental health, and the most efficient method of correcting the problem is orthodontic treatment with orthodontic appliances. The study was conducted to investigate the metal composition of selected orthodontic alloys, the release of metal ions, and the oxidative consequences that the metal ions may cause in the cell. Different sets of archwires, stainless steel brackets, and molar bands were incubated in artificial saliva for 90 days. The composition of each orthodontic material and quantification of the concentration of metal ions released were evaluated. Metal ion mixtures were prepared to determine the occurrence of oxidative stress, antioxidant enzyme defense system, and oxidative damage to proteins. The beta titanium alloy released the fewest metal ions and did not cause oxidative stress or protein damage. The metal ions from stainless steel and the cobalt-chromium alloy can cause oxidative stress and protein damage only at high concentrations. All metal ions from orthodontic alloys alter the activity of antioxidant enzymes in some way. The determined amounts of metal ions released from orthodontic appliances in a simulated oral environment are still below the maximum tolerated dose, and the concentrations of released metal ions are not capable of inducing oxidative stress, although some changes in antioxidant enzyme activity were observed at these concentrations.

• Jezik: Angleški jezik
• Ključne besede: orthodontic appliance, metal ion release, oxidative stress, ROS, antioxidative defense
• Vrsta gradiva: Članek v reviji
• Tipologija: 1.01 - Izvirni znanstveni članek
• Organizacija: ZF - Zdravstvena fakulteta ; MF - Medicinska fakulteta ; BF - Biotehniška fakulteta
• Status publikacije: Objavljeno
• Različica publikacije: Objavljena publikacija
• Leto izida: 2022
• Št. strani: 24 str.
• Številčenje: Vol. 11, iss. 1, art. 63
• PID: 20.500.12556/RUL-136783
• UDK: 616.314-089.23:546.7:66.094.3.097.8
• ISSN pri članku: 2076-3921
• DOI: 10.3390/antiox11010063
• COBISS.SI-ID: 91359235
• Datum objave v RUL: 20.05.2022

Gradivo je del revije

• Naslov: Antioxidants
• Skrajšan naslov: Antioxidants
• Založnik: MDPI
• ISSN: 2076-3921
• COBISS.SI-ID: 522976025

Licence

• Licenca: CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
• Povezava: http://creativecommons.org/licenses/by/4.0/deed.sl
• Opis: To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.
• Začetek licenciranja: 01.01.2022

Sekundarni jezik

• Jezik: Slovenski jezik
• Ključne besede: ortodontski pripomočki, oksidativni stres, kovinski ioni, vpliv na zdravje, antioksidanti