Causation of oxidative stress and defense response of a yeast cell model after treatment with orthodontic alloys consisting of metal ions

Kovač, Vito (author), Bergant, Matic (author), Ščančar, Janez (author), Primožič, Jasmina (author), Jamnik, Polona (author), Poljšak, Borut (author)

Misaligned teeth have a tremendous impact on oral and dental health, and the most efficient method of correcting the problem is orthodontic treatment with orthodontic appliances. The study was conducted to investigate the metal composition of selected orthodontic alloys, the release of metal ions, and the oxidative consequences that the metal ions may cause in the cell. Different sets of archwires, stainless steel brackets, and molar bands were incubated in artificial saliva for 90 days. The composition of each orthodontic material and quantification of the concentration of metal ions released were evaluated. Metal ion mixtures were prepared to determine the occurrence of oxidative stress, antioxidant enzyme defense system, and oxidative damage to proteins. The beta titanium alloy released the fewest metal ions and did not cause oxidative stress or protein damage. The metal ions from stainless steel and the cobalt-chromium alloy can cause oxidative stress and protein damage only at high concentrations. All metal ions from orthodontic alloys alter the activity of antioxidant enzymes in some way. The determined amounts of metal ions released from orthodontic appliances in a simulated oral environment are still below the maximum tolerated dose, and the concentrations of released metal ions are not capable of inducing oxidative stress, although some changes in antioxidant enzyme activity were observed at these concentrations.

• Language: English
• Keywords: orthodontic appliance, metal ion release, oxidative stress, ROS, antioxidative defense
• Work type: Article
• Typology: 1.01 - Original Scientific Article
• Organization: ZF - Faculty of Health Sciences; MF - Faculty of Medicine; BF - Biotechnical Faculty
• Publication status: Published
• Publication version: Version of Record
• Year: 2022
• Number of pages: 24 str.
• Numbering: Vol. 11, iss. 1, art. 63
• PID: 20.500.12556/RUL-136783
• UDC: 616.314-089.23:546.7:66.094.3.097.8
• ISSN on article: 2076-3921
• DOI: 10.3390/antiox11010063
• COBISS.SI-ID: 91359235
• Publication date in RUL: 20.05.2022

Record is a part of a journal

• Title: Antioxidants
• Shortened title: Antioxidants
• Publisher: MDPI
• ISSN: 2076-3921
• COBISS.SI-ID: 522976025

Licences

• License: CC BY 4.0, Creative Commons Attribution 4.0 International
• Link: http://creativecommons.org/licenses/by/4.0/
• Description: This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.
• Licensing start date: 01.01.2022

Secondary language

• Language: Slovenian
• Keywords: ortodontski pripomočki, oksidativni stres, kovinski ioni, vpliv na zdravje, antioksidanti