Effects of pre-term birth on the cardio-respiratory responses to hypoxic exercise in children

Narang, Benjamin J. (avtor), Manferdelli, Giorgio (avtor), Kepic, Katja (avtor), Sotiridis, Alexandros (avtor), Osredkar, Damjan (avtor), Bourdillon, Nicolas (avtor), Millet, Grégoire P. (avtor), Debevec, Tadej (avtor)

Pre-term birth is associated with numerous cardio-respiratory sequelae in children. Whether these impairments impact the responses to exercise in normoxia or hypoxia remains to be established. Fourteen prematurely-born (PREM) (Mean ± SD; gestational age 29 ± 2 weeks; age 9.5 ± 0.3 years), and 15 full-term children (CONT) (gestational age 39 ± 1 weeks; age 9.7 ± 0.9 years), underwent incremental exercise tests to exhaustion in normoxia (FiO$_2$ = 20.9%) and normobaric hypoxia (FiO$_2$ = 13.2%) on a cycle ergometer. Cardio-respiratory variables were measured throughout. Peak power output was higher in normoxia than hypoxia (103 ± 17 vs. 77 ± 18 W; p < 0.001), with no difference between CONT and PREM (94 ± 23 vs. 86 ± 19 W; p = 0.154). VO$_2$peak was higher in normoxia than hypoxia in CONT (50.8 ± 7.2 vs. 43.8 ± 9.9 mL·kg$^{−1}$·min$^{−1}$; p < 0.001) but not in PREM (48.1 ± 7.5 vs. 45.0 ± 6.8 mL·kg$^{−1}$·min$^{−1}$; p = 0.137; interaction p = 0.044). Higher peak heart rate (187 ± 11 vs. 180 ± 10 bpm; p = 0.005) and lower stroke volume (72 ± 13 vs. 77 ± 14 mL; p = 0.004) were observed in normoxia versus hypoxia in CONT, with no such differences in PREM (p = 0.218 and >0.999, respectively). In conclusion, premature birth does not appear to exacerbate the negative effect of hypoxia on exercise capacity in children. Further research is warranted to identify whether prematurity elicits a protective effect, and to clarify the potential underlying mechanisms.

• Jezik: Angleški jezik
• Ključne besede: altitude, children, hypoxia, exercise capacity, prematurity
• Vrsta gradiva: Članek v reviji
• Tipologija: 1.01 - Izvirni znanstveni članek
• Organizacija: FŠ - Fakulteta za šport
• Status publikacije: Objavljeno
• Različica publikacije: Objavljena publikacija
• Leto izida: 2022
• Št. strani: 11 str.
• Številčenje: Vol. 12, iss. 1, art. 79
• PID: 20.500.12556/RUL-136744
• UDK: 612
• ISSN pri članku: 2075-1729
• DOI: 10.3390/life12010079
• COBISS.SI-ID: 92421891
• Datum objave v RUL: 19.05.2022

Gradivo je del revije

• Naslov: Life
• Skrajšan naslov: Life
• Založnik: MDPI
• ISSN: 2075-1729
• COBISS.SI-ID: 519982617

Licence

• Licenca: CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
• Povezava: http://creativecommons.org/licenses/by/4.0/deed.sl
• Opis: To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.
• Začetek licenciranja: 06.01.2022

Sekundarni jezik

• Jezik: Slovenski jezik
• Ključne besede: nadmorska višina, otroci, hipoksija

Projekti

• Financer: ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
• Številka projekta: J3-7536
• Naslov: Kardiorespiratorni odzivi med hipoksično vadbo pri prezgodaj rojenih posameznikih

• Financer: ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
• Številka projekta: N5-0152
• Naslov: Mehanizmi hipoksične (in)tolerance pri predčasno rojenih posameznikih