Highly sensitive amperometric detection of hydrogen peroxide in saliva based on N-doped graphene nanoribbons and MnO$_2$ modified carbon paste electrodes

Gričar, Ema (avtor), Kalcher, Kurt (avtor), Genorio, Boštjan (avtor), Kolar, Mitja (avtor)

Four different graphene-based nanomaterials (htGO, N-htGO, htGONR, and N-htGONR) were synthesized, characterized, and used as a modifier of carbon paste electrode (CPE) in order to produce a reliable, precise, and highly sensitive non-enzymatic amperometric hydrogen peroxide sensor for complex matrices. CPE, with their robustness, reliability, and ease of modification, present a convenient starting point for the development of new sensors. Modification of CPE was optimized by systematically changing the type and concentration of materials in the modifier and studying the prepared electrode surface by cyclic voltammetry. N-htGONR in combination with manganese dioxide (1:1 ratio) proved to be the most appropriate material for detection of hydrogen peroxide in pharmaceutical and saliva matrices. The developed sensor exhibited a wide linear range (1.0–300 µM) and an excellent limit of detection (0.08 µM) and reproducibility, as well as high sensitivity and stability. The sensor was successfully applied to real sample analysis, where the recovery values for a commercially obtained pharmaceutical product were between 94.3% and 98.0%. Saliva samples of a user of the pharmaceutical product were also successfully analyzed.

• Jezik: Angleški jezik
• Ključne besede: electrochemical sensors, hydrogen peroxide, graphene, graphene nanoribbons, amperometry
• Vrsta gradiva: Članek v reviji
• Tipologija: 1.01 - Izvirni znanstveni članek
• Organizacija: FKKT - Fakulteta za kemijo in kemijsko tehnologijo
• Status publikacije: Objavljeno
• Različica publikacije: Objavljena publikacija
• Leto izida: 2021
• Št. strani: 13 str.
• Številčenje: Vol. 21, iss. 24, art. 8301
• PID: 20.500.12556/RUL-136594
• UDK: 543.553
• ISSN pri članku: 1424-8220
• DOI: 10.3390/s21248301
• COBISS.SI-ID: 89121539
• Datum objave v RUL: 12.05.2022

Gradivo je del revije

• Naslov: Sensors
• Skrajšan naslov: Sensors
• Založnik: MDPI
• ISSN: 1424-8220
• COBISS.SI-ID: 10176278

Licence

• Licenca: CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
• Povezava: http://creativecommons.org/licenses/by/4.0/deed.sl
• Opis: To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.
• Začetek licenciranja: 11.12.2021

Sekundarni jezik

• Jezik: Slovenski jezik
• Ključne besede: elektrokemijski senzorji, vodikov peroksid, grafen, grafenski nanotrakovi, amperometrija