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Integrative map of HIF1A regulatory elements and variations
ID
Kunej, Tanja
(
Avtor
)
PDF - Predstavitvena datoteka,
prenos
(3,99 MB)
MD5: A34DCD0A986DB4BDE36DD0ED73777D4B
URL - Izvorni URL, za dostop obiščite
https://www.mdpi.com/2073-4425/12/10/1526
Galerija slik
Izvleček
Hypoxia-inducible factor (HIF) family of transcription factors (HIF1A, EPAS1, and HIF3A) are regulators of the cellular response to hypoxia. They have been shown to be involved in development of various diseases such as cancer, diabetes, and erythrocytosis. A complete map of connections between HIF family of genes with various omics types has not yet been developed. The main aim of the present analysis was to construct the integrative map of genomic elements associated with HIF1A gene and prioritize potentially deleterious variants. Various genomic databases and bioinformatics tools were used, including Ensembl, MirTarBase, STRING, Cytoscape, MethPrimer, CADD, SIFT, and UALCAN. Integrative HIF1A gene map was visualized and includes transcriptional and post-transcriptional regulators, downstream targets, and genetic variants. One CpG island overlaps transcription start site of the HIF1A gene. Out of over 450 missense variants, four have predicted deleterious effect on protein function by at least five bioinformatics tools. Currently there are 85 miRNAs reported to target HIF1A. HIF1A downstream targets include protein-coding genes, long noncoding RNAs, and microRNAs (hypoxamiRs). The study presents the first integration of heterogeneous molecular interactions associated with HIF1A gene enabling a holistic view of the gene and lays the groundwork for supplementing the data in the future.
Jezik:
Angleški jezik
Ključne besede:
cancer
,
erythrocytosis
,
hypoxia-inducible factor (HIF)
,
HIF1A
,
hypoxia
Vrsta gradiva:
Članek v reviji
Tipologija:
1.01 - Izvirni znanstveni članek
Organizacija:
BF - Biotehniška fakulteta
Status publikacije:
Objavljeno
Različica publikacije:
Objavljena publikacija
Leto izida:
2021
Št. strani:
14 str.
Številčenje:
Vol. 12, iss. 10, art. 1526
PID:
20.500.12556/RUL-136295
UDK:
61:575
ISSN pri članku:
2073-4425
DOI:
10.3390/genes12101526
COBISS.SI-ID:
78556675
Datum objave v RUL:
22.04.2022
Število ogledov:
553
Število prenosov:
75
Metapodatki:
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Objavi na:
Gradivo je del revije
Naslov:
Genes
Skrajšan naslov:
Genes
Založnik:
Multidisciplinary Digital Publishing Institute (MDPI)
ISSN:
2073-4425
COBISS.SI-ID:
523100185
Licence
Licenca:
CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
Povezava:
http://creativecommons.org/licenses/by/4.0/deed.sl
Opis:
To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.
Začetek licenciranja:
01.10.2021
Sekundarni jezik
Jezik:
Slovenski jezik
Ključne besede:
medicina
,
rak
,
eritrocitoza
,
genetika
,
HIF
,
HIF1A
,
hipoksija
Projekti
Financer:
ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
Številka projekta:
L3-9279
Naslov:
Genetska osnova eritrocitoz v Sloveniji
Financer:
ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
Številka projekta:
P4-0220
Naslov:
Primerjalna genomika in genomska biodiverziteta
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