Risk assessment of oxidative stress induced by metal ions released from fixed orthodontic appliances during treatment and indications for supportive antioxidant therapy : a narrative review

Primožič, Jasmina (author), Poljšak, Borut (author), Jamnik, Polona (author), Kovač, Vito (author), Čanadi-Jurešić, Gordana (author), Špalj, Stjepan (author)

The treatment with fixed orthodontic appliances could have an important role in the induction of oxidative stress and associated negative consequences. Because of the simultaneous effects of corrosion, deformation, friction, and mechanical stress on fixed orthodontic appliances during treatment, degradation of orthodontic brackets and archwires occurs, causing higher concentrations of metal ions in the oral cavity. Corroded appliances cause the release of metal ions, which may lead to the increased values of reactive oxygen species (ROS) due to metal-catalyzed free radical reactions. Chromium, iron, nickel, cobalt, titanium, and molybdenum all belong to the group of transition metals that can be subjected to redox reactions to form ROS. The estimation of health risk due to the amount of heavy metals released and the level of selected parameters of oxidative stress generated for the time of treatment with fixed orthodontic appliances is presented. Approaches to avoid oxidative stress and recommendations for the preventive use of topical or systemic antioxidants during orthodontic treatment are discussed.

• Language: English
• Keywords: fixed orthodontic appliances, oxidative stress, metal ions, risk assessment, antioxidant therapy
• Work type: Article
• Typology: 1.02 - Review Article
• Organization: MF - Faculty of Medicine; ZF - Faculty of Health Sciences; BF - Biotechnical Faculty
• Publication status: Published
• Publication version: Version of Record
• Year: 2021
• Number of pages: 17 str.
• Numbering: Vol. 10, iss. 9, art. 1359
• PID: 20.500.12556/RUL-136042
• UDC: 616.314-089.23:546.7:66.094.3.097.8
• ISSN on article: 2076-3921
• DOI: 10.3390/antiox10091359
• COBISS.SI-ID: 74268163
• Publication date in RUL: 08.04.2022

Record is a part of a journal

• Title: Antioxidants
• Shortened title: Antioxidants
• Publisher: MDPI
• ISSN: 2076-3921
• COBISS.SI-ID: 522976025

Licences

• License: CC BY 4.0, Creative Commons Attribution 4.0 International
• Link: http://creativecommons.org/licenses/by/4.0/
• Description: This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.
• Licensing start date: 01.09.2021

Secondary language

• Language: Slovenian
• Keywords: ortodontski pripomočki, oksidativni stres, kovinski ioni, vpliv na zdravje, antioksidanti