Mechanical and electrical interaction of biological membranes with nanoparticles and nanostructured surfaces

Raval, Jeel (author), Gongadze, Ekaterina (author), Benčina, Metka (author), Junkar, Ita (author), Rawat, Niharika (author), Mesarec, Luka (author), Kralj-Iglič, Veronika (author), Góźdź, Wojciech (author), Iglič, Aleš (author)

In this review paper, we theoretically explain the origin of electrostatic interactions between lipid bilayers and charged solid surfaces using a statistical mechanics approach, where the orientational degree of freedom of lipid head groups and the orientational ordering of the water dipoles are considered. Within the modified Langevin Poisson–Boltzmann model of an electric double layer, we derived an analytical expression for the osmotic pressure between the planar zwitterionic lipid bilayer and charged solid planar surface. We also show that the electrostatic interaction between the zwitterionic lipid head groups of the proximal leaflet and the negatively charged solid surface is accompanied with a more perpendicular average orientation of the lipid head-groups. We further highlight the important role of the surfaces’ nanostructured topography in their interactions with biological material. As an example of nanostructured surfaces, we describe the synthesis of TiO$_2$ nanotubular and octahedral surfaces by using the electrochemical anodization method and hydrothermal method, respectively. The physical and chemical properties of these nanostructured surfaces are described in order to elucidate the influence of the surface topography and other physical properties on the behavior of human cells adhered to TiO$_2$ nanostructured surfaces. In the last part of the paper, we theoretically explain the interplay of elastic and adhesive contributions to the adsorption of lipid vesicles on the solid surfaces. We show the numerically predicted shapes of adhered lipid vesicles corresponding to the minimum of the membrane free energy to describe the influence of the vesicle size, bending modulus, and adhesion strength on the adhesion of lipid vesicles on solid charged surfaces.

• Language: English
• Keywords: lipid bilayer electrostatics, zwitterionic lipid bilayers, electric double layer, osmotic pressure, orientational degree of freedom of lipid headgroups, orientational ordering of water dipoles, adhesion of lipid vesicles, lipid bilayer elasticity, lipid vesicle shapes
• Work type: Article
• Typology: 1.02 - Review Article
• Organization: FE - Faculty of Electrical Engineering; ZF - Faculty of Health Sciences; MF - Faculty of Medicine
• Publication status: Published
• Publication version: Version of Record
• Year: 2021
• Number of pages: 20 str.
• Numbering: Vol. 11, iss. 7, art. 533
• PID: 20.500.12556/RUL-136016
• UDC: 577
• ISSN on article: 2077-0375
• DOI: 10.3390/membranes11070533
• COBISS.SI-ID: 70365955
• Publication date in RUL: 06.04.2022

Record is a part of a journal

• Title: Membranes
• Shortened title: Membranes
• Publisher: MDPI
• ISSN: 2077-0375
• COBISS.SI-ID: 519125529

Licences

• License: CC BY 4.0, Creative Commons Attribution 4.0 International
• Link: http://creativecommons.org/licenses/by/4.0/
• Description: This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.
• Licensing start date: 14.07.2021

Secondary language

• Language: Slovenian
• Keywords: elektrostatski lipidni dvosloj, zwitterionski lipidni dvosloj, električni dvojni sloj, osmotski tlak, svobodna orientacijska stopnja lipidnih skupin, orientirano urejanje vodnih dipolov, adhezija lipidnih veziklov, elastičnost lipidnih dvoslojev, oblike lipidnh veziklov