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Comparison of clinical, laboratory and immune characteristics of the monophasic and biphasic course of tick-borne encephalitis
ID
Bogovič, Petra
(
Author
),
ID
Lotrič-Furlan, Stanka
(
Author
),
ID
Avšič-Županc, Tatjana
(
Author
),
ID
Korva, Miša
(
Author
),
ID
Kastrin, Andrej
(
Author
),
ID
Lusa, Lara
(
Author
),
ID
Strle, Klemen
(
Author
),
ID
Strle, Franc
(
Author
)
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MD5: 1089A951694C78DBC6B2C4D021AF0499
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https://www.mdpi.com/2076-2607/9/4/796
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Abstract
The biphasic course of tick-borne encephalitis (TBE) is well described, but information on the monophasic course is limited. We assessed and compared the clinical presentation, laboratory findings, and immune responses in 705 adult TBE patients: 283 with monophasic and 422 with biphasic course. Patients with the monophasic course were significantly (p ≤ 0.002) older (57 vs. 50 years), more often vaccinated against TBE (7.4% vs. 0.9%), more often had comorbidities (52% vs. 37%), and were more often treated in the intensive care unit (12.4% vs. 5.2%). Multivariate logistic regression found strong association between the monophasic TBE course and previous TBE vaccination (OR = 18.45), presence of underlying illness (OR = 1.85), duration of neurologic involvement before cerebrospinal fluid (CSF) examination (OR = 1.39), and patients’ age (OR = 1.02). Furthermore, patients with monophasic TBE had higher CSF levels of immune mediators associated with innate and adaptive (Th1 and B-cell) immune responses, and they had more pronounced disruption of the blood–brain barrier. However, the long-term outcome 2–7 years after TBE was comparable. In summary, the monophasic course is a frequent and distinct presentation of TBE that is associated with more difficult disease course and higher levels of inflammatory mediators in CSF than the biphasic course; however, the long-term outcome is similar.
Language:
English
Keywords:
tick-borne encephalitis
,
monophasic course
,
biphasic course
,
long-term outcome
,
cerebrospinal fluid
,
cytokines
,
chemokines
,
innate immune responses
,
adaptive immune responses
Work type:
Article
Typology:
1.01 - Original Scientific Article
Organization:
MF - Faculty of Medicine
Publication status:
Published
Publication version:
Version of Record
Year:
2021
Number of pages:
12 str.
Numbering:
Vol. 9, iss. 4, art. 796
PID:
20.500.12556/RUL-135544
UDC:
606.9
ISSN on article:
2076-2607
DOI:
10.3390/microorganisms9040796
COBISS.SI-ID:
59073539
Publication date in RUL:
18.03.2022
Views:
730
Downloads:
110
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Record is a part of a journal
Title:
Microorganisms
Shortened title:
Microorganisms
Publisher:
MDPI AG
ISSN:
2076-2607
COBISS.SI-ID:
523277081
Licences
License:
CC BY 4.0, Creative Commons Attribution 4.0 International
Link:
http://creativecommons.org/licenses/by/4.0/
Description:
This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.
Licensing start date:
10.04.2021
Secondary language
Language:
Slovenian
Keywords:
klopni encefalitis
,
cerebralna tekočina
,
citokini
,
imunski odziv
Projects
Funder:
ARRS - Slovenian Research Agency
Project number:
P3-0296
Name:
Bolezni in povzročitelji, ki jih v Sloveniji prenašajo členonožci
Funder:
ARRS - Slovenian Research Agency
Project number:
J3-1744
Name:
Poglobljena analiza vplivov dejavnikov povzročitelja in gostitelja pri akutni in kronični lymski boreliozi
Funder:
ARRS - Slovenian Research Agency
Project number:
J3-8195
Name:
Dejavniki povzročitelja in gostitelja, ki vplivajo na klinične znake, težo in izid lymske borelioze
Funder:
NIH - National Institutes of Health
Project number:
R21 AI144916
Funder:
Other - Other funder or multiple funders
Funding programme:
MGH-ECOR
Funder:
Other - Other funder or multiple funders
Funding programme:
Global Lyme Alliance
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