A novel reduced graphene oxide modified carbon paste electrode for potentiometric determination of trihexyphenidyl hydrochloride in pharmaceutical and biological matrices

Radić, Josip (avtor), Buljac, Maša (avtor), Genorio, Boštjan (avtor), Gričar, Ema (avtor), Kolar, Mitja (avtor)

A novel promising carbon paste electrode with excellent potentiometric properties was prepared for the analysis of trihexyphenidyl hydrochloride (THP), the acetylcholine receptor and an anticholinergic drug in real samples. It contains 10.2% trihexyphenidy-tetraphenylborate ionic pair as the electroactive material, with the addition of 3.9% reduced graphene oxide and 0.3% of anionic additive into the paste, which consists of 45.0% dibutylphthalate as the solvent mediator and 40.6% graphite. Under the optimized experimental conditions, the electrode showed a Nernstian slope of 58.9 ± 0.2 mV/decade with a regression coefficient of 0.9992. It exhibited high selectivity and reproducibility as well as a fast and linear dynamic response range from 4.0 × 10$^{−7}$ to 1.0 × 10$^{−2}$ M. The electrode remained usable for up to 19 days. Analytical applications showed excellent recoveries ranging from 96.8 to 101.7%, LOD was 2.5 × 10$^{−7}$ M. The electrode was successfully used for THP analysis of pharmaceutical and biological samples.

• Jezik: Angleški jezik
• Ključne besede: potentiometry, carbon paste electrode, reduced graphene oxide, trihexyphenidyl hydrochloride, pharmaceuticals, urine samples
• Vrsta gradiva: Članek v reviji
• Tipologija: 1.01 - Izvirni znanstveni članek
• Organizacija: FKKT - Fakulteta za kemijo in kemijsko tehnologijo
• Status publikacije: Objavljeno
• Različica publikacije: Objavljena publikacija
• Leto izida: 2021
• Št. strani: 14 str.
• Številčenje: Vol. 21, iss. 9, art. 2955
• PID: 20.500.12556/RUL-135315
• UDK: 543.554
• ISSN pri članku: 1424-8220
• DOI: 10.3390/s21092955
• COBISS.SI-ID: 61633027
• Datum objave v RUL: 07.03.2022

Gradivo je del revije

• Naslov: Sensors
• Skrajšan naslov: Sensors
• Založnik: MDPI
• ISSN: 1424-8220
• COBISS.SI-ID: 10176278

Licence

• Licenca: CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
• Povezava: http://creativecommons.org/licenses/by/4.0/deed.sl
• Opis: To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.
• Začetek licenciranja: 01.05.2021

Sekundarni jezik

• Jezik: Slovenski jezik
• Ključne besede: potenciometrija, elektrode iz ogljikove paste, reduciran grafen oksid, triheksifenidil hidroklorid, farmacevtske učinkovine, urinski vzorci