A novel reduced graphene oxide modified carbon paste electrode for potentiometric determination of trihexyphenidyl hydrochloride in pharmaceutical and biological matrices

Radić, Josip (author), Buljac, Maša (author), Genorio, Boštjan (author), Gričar, Ema (author), Kolar, Mitja (author)

A novel promising carbon paste electrode with excellent potentiometric properties was prepared for the analysis of trihexyphenidyl hydrochloride (THP), the acetylcholine receptor and an anticholinergic drug in real samples. It contains 10.2% trihexyphenidy-tetraphenylborate ionic pair as the electroactive material, with the addition of 3.9% reduced graphene oxide and 0.3% of anionic additive into the paste, which consists of 45.0% dibutylphthalate as the solvent mediator and 40.6% graphite. Under the optimized experimental conditions, the electrode showed a Nernstian slope of 58.9 ± 0.2 mV/decade with a regression coefficient of 0.9992. It exhibited high selectivity and reproducibility as well as a fast and linear dynamic response range from 4.0 × 10$^{−7}$ to 1.0 × 10$^{−2}$ M. The electrode remained usable for up to 19 days. Analytical applications showed excellent recoveries ranging from 96.8 to 101.7%, LOD was 2.5 × 10$^{−7}$ M. The electrode was successfully used for THP analysis of pharmaceutical and biological samples.

• Language: English
• Keywords: potentiometry, carbon paste electrode, reduced graphene oxide, trihexyphenidyl hydrochloride, pharmaceuticals, urine samples
• Work type: Article
• Typology: 1.01 - Original Scientific Article
• Organization: FKKT - Faculty of Chemistry and Chemical Technology
• Publication status: Published
• Publication version: Version of Record
• Year: 2021
• Number of pages: 14 str.
• Numbering: Vol. 21, iss. 9, art. 2955
• PID: 20.500.12556/RUL-135315
• UDC: 543.554
• ISSN on article: 1424-8220
• DOI: 10.3390/s21092955
• COBISS.SI-ID: 61633027
• Publication date in RUL: 07.03.2022

Record is a part of a journal

• Title: Sensors
• Shortened title: Sensors
• Publisher: MDPI
• ISSN: 1424-8220
• COBISS.SI-ID: 10176278

Licences

• License: CC BY 4.0, Creative Commons Attribution 4.0 International
• Link: http://creativecommons.org/licenses/by/4.0/
• Description: This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.
• Licensing start date: 01.05.2021

Secondary language

• Language: Slovenian
• Keywords: potenciometrija, elektrode iz ogljikove paste, reduciran grafen oksid, triheksifenidil hidroklorid, farmacevtske učinkovine, urinski vzorci