Genetics and the development of molecular methods are making tremendous progress. Therefore, it is increasingly important that the new knowledge is incorporated unhindered into school curriculum as a basis and inspiration for the further study of future study biologistresearchers. The importance of linking advanced science to basic science and general knowledge in the high school has been established as the core of our research. The knowledge which is the subject of our research has proven to be very important for the general public and understanding of the coronavirus epidemic. The aim of the study was to investigate the effect of two different teaching methods on the attitude and knowledge of students in the biology subject of general high school in relation to the application of one of the most commonly used techniques in molecular biology - electrophoresis. The study was conducted using a coded questionnaire including a knowledge test which students solved before and after classes with frontal instruction and demonstration. We found that demonstration teaching had a greater effect on the students' knowledge of electrophoresis, although both methods had an effect. Students showed a low level of general prior knowledge about electrophoresis. The results showed a slight gender difference in knowledge, preference for hands-on work, and attitude toward electrophoresis, especially in favor of girls. More knowledge and greater agreement with scientific views were shown by students with a researcher-scientist in the family and those who were pursuing scientific studies. On examination, students showed an awareness of the need for practical work and the acquisition of skills and abilities in learning molecular biology techniques to facilitate the understanding of these contents.
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