Wide-antimicrobial spectrum of picolinium salts

Salajkova, Sarka (avtor), Benkova, Marketa (avtor), Marek, Jan (avtor), Sleha, Radek (avtor), Prchal, Lukáš (avtor), Malinak, David (avtor), Dolezal, Rafael (avtor), Sepčić, Kristina (avtor), Gunde-Cimerman, Nina (avtor), Kuca, Kamil (avtor), Soukup, Ondrej (avtor)

Nosocomial infections, which greatly increase morbidity among hospitalized patients, together with growing antibiotic resistance still encourage many researchers to search for novel antimicrobial compounds. Picolinium salts with different lengths of alkyl chains (C$_{12}$, C$_{14}$, C$_{16}$) were prepared by Menshutkin-like reaction and evaluated with respect to their biological activity, i.e., lipophilicity and critical micellar concentration. Picolinium salts with C$_{14}$ and C$_{16}$ side chains achieved similar or even better results when in terms of antimicrobial efficacy than benzalkoniums; notably, their fungicidal efficiency was substantially more potent. The position of the methyl substituent on the aromatic ring does not seem to affect antimicrobial activity, in contrast to the effect of length of the N-alkyl chain. Concurrently, picolinium salts exhibited satisfactory low cytotoxicity against mammalian cells, i.e., lower than that of benzalkonium compounds, which are considered as safe.

• Jezik: Angleški jezik
• Ključne besede: picolinium salts, quaternary ammonium compounds, surfactant, critical micellar concentration, antimicrobial activity, cytotoxicity
• Vrsta gradiva: Članek v reviji
• Tipologija: 1.01 - Izvirni znanstveni članek
• Organizacija: BF - Biotehniška fakulteta
• Status publikacije: Objavljeno
• Različica publikacije: Objavljena publikacija
• Leto izida: 2020
• Št. strani: 16 str.
• Številčenje: Vol. 25, iss. 9, art. 2254
• PID: 20.500.12556/RUL-133711
• UDK: 577
• ISSN pri članku: 1420-3049
• DOI: 10.3390/molecules25092254
• COBISS.SI-ID: 14885123
• Datum objave v RUL: 10.12.2021

Gradivo je del revije

• Naslov: Molecules
• Skrajšan naslov: Molecules
• Založnik: MDPI
• ISSN: 1420-3049
• COBISS.SI-ID: 18462981

Licence

• Licenca: CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
• Povezava: http://creativecommons.org/licenses/by/4.0/deed.sl
• Opis: To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.
• Začetek licenciranja: 11.05.2020

Sekundarni jezik

• Jezik: Slovenski jezik
• Ključne besede: pikolinijeve soli, kvartarne amonijeve spojine, surfaktant, kritična micelarna koncentracija, protimikrobna aktivnost, citotoksičnost

Projekti

• Financer: Drugi - Drug financer ali več financerjev
• Program financ.: Czech Health Research Council
• Številka projekta: NV19-09-00198