Wide-antimicrobial spectrum of picolinium salts

Salajkova, Sarka (author), Benkova, Marketa (author), Marek, Jan (author), Sleha, Radek (author), Prchal, Lukáš (author), Malinak, David (author), Dolezal, Rafael (author), Sepčić, Kristina (author), Gunde-Cimerman, Nina (author), Kuca, Kamil (author), Soukup, Ondrej (author)

Nosocomial infections, which greatly increase morbidity among hospitalized patients, together with growing antibiotic resistance still encourage many researchers to search for novel antimicrobial compounds. Picolinium salts with different lengths of alkyl chains (C$_{12}$, C$_{14}$, C$_{16}$) were prepared by Menshutkin-like reaction and evaluated with respect to their biological activity, i.e., lipophilicity and critical micellar concentration. Picolinium salts with C$_{14}$ and C$_{16}$ side chains achieved similar or even better results when in terms of antimicrobial efficacy than benzalkoniums; notably, their fungicidal efficiency was substantially more potent. The position of the methyl substituent on the aromatic ring does not seem to affect antimicrobial activity, in contrast to the effect of length of the N-alkyl chain. Concurrently, picolinium salts exhibited satisfactory low cytotoxicity against mammalian cells, i.e., lower than that of benzalkonium compounds, which are considered as safe.

• Language: English
• Keywords: picolinium salts, quaternary ammonium compounds, surfactant, critical micellar concentration, antimicrobial activity, cytotoxicity
• Work type: Article
• Typology: 1.01 - Original Scientific Article
• Organization: BF - Biotechnical Faculty
• Publication status: Published
• Publication version: Version of Record
• Year: 2020
• Number of pages: 16 str.
• Numbering: Vol. 25, iss. 9, art. 2254
• PID: 20.500.12556/RUL-133711
• UDC: 577
• ISSN on article: 1420-3049
• DOI: 10.3390/molecules25092254
• COBISS.SI-ID: 14885123
• Publication date in RUL: 10.12.2021

Record is a part of a journal

• Title: Molecules
• Shortened title: Molecules
• Publisher: MDPI
• ISSN: 1420-3049
• COBISS.SI-ID: 18462981

Licences

• License: CC BY 4.0, Creative Commons Attribution 4.0 International
• Link: http://creativecommons.org/licenses/by/4.0/
• Description: This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.
• Licensing start date: 11.05.2020

Secondary language

• Language: Slovenian
• Keywords: pikolinijeve soli, kvartarne amonijeve spojine, surfaktant, kritična micelarna koncentracija, protimikrobna aktivnost, citotoksičnost

Projects

• Funder: Other - Other funder or multiple funders
• Funding programme: Czech Health Research Council
• Project number: NV19-09-00198