Current view on EpCAM structural biology

Gaber, Aljaž (avtor), Lenarčič, Brigita (avtor), Pavšič, Miha (avtor)

EpCAM, a carcinoma cell-surface marker protein and a therapeutic target, has been primarily addressed as a cell adhesion molecule. With regard to recent discoveries of its role in signaling with implications in cell proliferation and differentiation, and findings contradicting a direct role in mediating adhesion contacts, we provide a comprehensive and updated overview on the available structural data on EpCAM and interpret it in the light of recent reports on its function. First, we describe the structure of extracellular part of EpCAM, both as a subunit and part of a cis-dimer which, according to several experimental observations, represents a biologically relevant oligomeric state. Next, we provide a thorough evaluation of reports on EpCAM as a homophilic cell adhesion molecule with a structure-based explanation why direct EpCAM participation in cell–cell contacts is highly unlikely. Finally, we review the signaling aspect of EpCAM with focus on accessibility of signaling-associated cleavage sites.

• Jezik: Angleški jezik
• Ključne besede: EpCAM, transmembrane protein, structure, dimer, adhesion, regulated intramembrane proteolysis, signaling, disease
• Vrsta gradiva: Članek v reviji
• Tipologija: 1.02 - Pregledni znanstveni članek
• Organizacija: FKKT - Fakulteta za kemijo in kemijsko tehnologijo
• Status publikacije: Objavljeno
• Različica publikacije: Objavljena publikacija
• Leto izida: 2020
• Št. strani: 18 str.
• Številčenje: Vol. 9, iss. 6, art. 1361
• PID: 20.500.12556/RUL-133666
• UDK: 577.112
• ISSN pri članku: 2073-4409
• DOI: 10.3390/cells9061361
• COBISS.SI-ID: 17857539
• Datum objave v RUL: 08.12.2021

Gradivo je del revije

• Naslov: Cells
• Skrajšan naslov: Cells
• Založnik: MDPI
• ISSN: 2073-4409
• COBISS.SI-ID: 519958809

Licence

• Licenca: CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
• Povezava: http://creativecommons.org/licenses/by/4.0/deed.sl
• Opis: To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.
• Začetek licenciranja: 01.06.2020

Sekundarni jezik

• Jezik: Slovenski jezik
• Ključne besede: EpCAM, transmembranski proteini, struktura, dimer, adhezija, regulirana znotrajmembranska proteoliza, signaliziranje, bolezni