Nanotechnology meets oncology : nanomaterials in brain cancer research, diagnosis and therapy

Zottel, Alja (author), Videtič Paska, Alja (author), Jovchevska, Ivana (author)

Advances in technology of the past decades led to development of new nanometer scale diagnosis and treatment approaches in cancer medicine leading to establishment of nanooncology. Inorganic and organic nanomaterials have been shown to improve bioimaging techniques and targeted drug delivery systems. Their favorable physico-chemical characteristics, like small sizes, large surface area compared to volume, specific structural characteristics, and possibility to attach different molecules on their surface transform them into excellent transport vehicles able to cross cell and/or tissue barriers, including the blood-brain barrier. The latter is one of the greatest challenges in diagnosis and treatment of brain cancers. Application of nanomaterials can prolong the circulation time of the drugs and contrasting agents in the brain, posing an excellent opportunity for advancing the treatment of the most aggressive form of the brain cancer-glioblastomas. However, possible unwanted side-effects and toxicity issues must be considered before final clinical translation of nanoparticles.

• Language: English
• Keywords: nanomaterials, brain cancer, nanomedicine, nanoparticles, nanobodies, blood–brain barrier, glioblastoma, nanodiagnostics, nanotherapy
• Work type: Article
• Typology: 1.02 - Review Article
• Organization: MF - Faculty of Medicine
• Publication status: Published
• Publication version: Version of Record
• Year: 2019
• Number of pages: 28 str.
• Numbering: Vol. 12, iss. 10, art. 1588
• PID: 20.500.12556/RUL-132244
• UDC: 616-006
• ISSN on article: 1996-1944
• DOI: 10.3390/ma12101588
• COBISS.SI-ID: 34313945
• Publication date in RUL: 19.10.2021

Record is a part of a journal

• Title: Materials
• Shortened title: Materials
• Publisher: MDPI
• ISSN: 1996-1944
• COBISS.SI-ID: 33588485

Licences

• License: CC BY 4.0, Creative Commons Attribution 4.0 International
• Link: http://creativecommons.org/licenses/by/4.0/
• Description: This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.
• Licensing start date: 15.05.2019

Secondary language

• Language: Slovenian
• Keywords: nanomateriali, rak možganov, nanomedicina