Inception mechanisms of tunneling nanotubes

Drab, Mitja (avtor), Stopar, David (avtor), Kralj-Iglič, Veronika (avtor), Iglič, Aleš (avtor)

Tunneling nanotubes (TNTs) are thin membranous tubes that interconnect cells, representing a novel route of cell-to-cell communication and spreading of pathogens. TNTs form between many cell types, yet their inception mechanisms remain elusive. We review in this study general concepts related to the formation and stability of membranous tubular structures with a focus on a deviatoric elasticity model of membrane nanodomains. We review experimental evidence that tubular structures initiate from local membrane bending facilitated by laterally distributed proteins or anisotropic membrane nanodomains. We further discuss the numerical results of several theoretical and simulation models of nanodomain segregation suggesting the mechanisms of TNT inception and stability. We discuss the coupling of nanodomain segregation with the action of protruding cytoskeletal forces, which are mostly provided in eukaryotic cells by the polymerization of f-actin, and review recent inception mechanisms of TNTs in relation to motor proteins.

• Jezik: Angleški jezik
• Ključne besede: tunneling nanotubes, filopodia, anisotropic membrane domains, cytoskeletal forces, f-actin
• Vrsta gradiva: Članek v reviji
• Tipologija: 1.02 - Pregledni znanstveni članek
• Organizacija: FE - Fakulteta za elektrotehniko; MF - Medicinska fakulteta ; BF - Biotehniška fakulteta ; ZF - Zdravstvena fakulteta
• Status publikacije: Objavljeno
• Različica publikacije: Objavljena publikacija
• Leto izida: 2019
• Št. strani: 17 str.
• Številčenje: Vol. 8, iss. 6, art. 626
• PID: 20.500.12556/RUL-132233
• UDK: 577
• ISSN pri članku: 2073-4409
• DOI: 10.3390/cells8060626
• COBISS.SI-ID: 12576084
• Datum objave v RUL: 18.10.2021

Gradivo je del revije

• Naslov: Cells
• Skrajšan naslov: Cells
• Založnik: MDPI
• ISSN: 2073-4409
• COBISS.SI-ID: 519958809

Licence

• Licenca: CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
• Povezava: http://creativecommons.org/licenses/by/4.0/deed.sl
• Opis: To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.
• Začetek licenciranja: 21.06.2019

Sekundarni jezik

• Jezik: Slovenski jezik
• Ključne besede: nanotube, filopodija, anizotropne membranske inkluzije, citoskeletne sile, f-aktin