The chemistry of fluorinated organic molecules has been extensively researched, but it certainly hides many surprises. Due to special chemical and physical properties of the C–F bond (this polar bond is one of the strongest single bonds), it has been the target of researchers for more than a hundred years. As a result, a huge number of compounds have been prepared to date, which are used in various fields (pharmacy, household appliances industry, materials chemistry...). In the first part of the master's thesis, I focused on the conversion of fluorinated and perfluorinated halides with thiophenol under classical conditions of nucleophilic substitution in acetonitrile in the presence of potassium carbonate. According to the literature data known so far, the synthesis of such sulfides is possible only by a radical or photochemical reaction. As part of the master's thesis, we therefore tried to determine whether it is true that synthesis is really not possible through nucleophilic substitution. Preliminary experiments have suggested that such an approach could be more widely used, as the reactions proceeded in the desired direction, i.e. to fluorinated and perfluorinated sulfides. The reactivity of some fluorinated and perfluorinated sulfides was tested by conversion to the corresponding sulfoxides. The use of N-chlorosuccinimide (NCS) as the oxidant has been shown to be successful only in cases of oxidation of fluorinated sulfides. In the case of perfluorinated sulfides, the reaction with NCS was not successful. The latter sulfides were further successfully oxidized with a 30% aqueous solution of hydrogen peroxide, where the reaction medium was most likely essential. In total, I successfully synthesized nine fluorinated sulfides, six perfluorinated sulfides, and seven corresponding sulfoxides.
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