Treatment of canine cognitive dysfunction with novel butyrylcholinesterase inhibitor

Zakošek, Maja (avtor), Prpar Mihevc, Sonja (avtor), Štrbenc, Malan (avtor), Košak, Urban (avtor), German Ilić, Ilija (avtor), Trontelj, Jurij (avtor), Žakelj, Simon (avtor), Gobec, Stanislav (avtor), Pavlin, Darja (avtor), Majdič, Gregor (avtor)

Canine cognitive dysfunction (CCD) is common in aged dogs and has many similarities with Alzheimer’s disease. Unfortunately, like Alzheimer’s disease, CCD cannot be cured. In the present study, we treated dogs with CCD with our newly developed and characterized butyrylcholinesterase inhibitor (BChEi). Seventeen dogs were randomized into two groups (treated with BChEi and untreated) and followed for 6 months at regular check-ups. The dogs’ cognitive status was determined by a Canine Dementia Scale (CADES) questionnaire and two cognitive tests. In dogs with moderate cognitive impairment, treatment caused significant improvement in the clinical rating of cognitive abilities and the performance-based tests of cognitive functioning when compared to the untreated group (p < 0.001). Dogs treated with BChEi showed markedly improved cognitive function with enhanced quality of life. No side effects were observed in the treated dogs with moderate cognitive impairment. According to the results of this preliminary study, there is an indication that novel BChEi may be a promising drug for the treatment of CCD in dogs and may be an interesting candidate for the treatment of Alzheimer's disease in humans. However, further clinical studies are needed to confirm this.

• Jezik: Angleški jezik
• Ključne besede: Alzheimer’s disease, butyrylcholinesterase, butyrylcholinesterase inhibitor, canine cognitive dysfunction, canine dementia scale, dogs
• Vrsta gradiva: Članek v reviji
• Tipologija: 1.01 - Izvirni znanstveni članek
• Organizacija: VF - Veterinarska fakulteta ; FFA - Fakulteta za farmacijo
• Status publikacije: Objavljeno
• Različica publikacije: Objavljena publikacija
• Poslano v recenzijo: 15.12.2020
• Datum sprejetja članka: 17.08.2021
• Datum objave: 13.09.2021
• Leto izida: 2021
• Št. strani: 10 str.
• Številčenje: Vol. 11, art. 18098
• PID: 20.500.12556/RUL-131180
• UDK: 636.7.09:616.892
• ISSN pri članku: 2045-2322
• DOI: 10.1038/s41598-021-97404-2
• COBISS.SI-ID: 77000195
• Datum objave v RUL: 23.09.2021

Gradivo je del revije

• Naslov: Scientific reports
• Skrajšan naslov: Sci. rep.
• Založnik: Nature Publishing Group
• ISSN: 2045-2322
• COBISS.SI-ID: 18727432

Licence

• Licenca: CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
• Povezava: http://creativecommons.org/licenses/by/4.0/deed.sl
• Opis: To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.
• Začetek licenciranja: 13.09.2021