Natural Deep Eutectic Solvents (NADES) to enhance berberine absorption : an in vivo pharmacokinetic study

Sut, Stefania (author), Faggian, Marta (author), Baldan, Valeria (author), Poloniato, Gabriele (author), Castagliuolo, Ignazio (author), Grabnar, Iztok (author), Perissutti, Beatrice (author), Brun, Paola (author), Maggi, Filippo (author), Voinovich, Dario (author), Peron, Gregorio (author), Dall'Acqua, Stefano (author)

In the present study results related to the in vivo administration of Natural Deep Eutectic Solvents (NADES)-solubilized berberine are reported for the first time. NADES are mixtures of small natural compounds having a melting point significantly lower than that of any individual component. Such solvents have gained much attention of the scientific community in the green chemistry area, being considered useful alternatives to common organic solvents. NADES can be used also as administration vehicles, and this can be attractive for nutraceutical products when eutectics are formed with food grade ingredients. In this work, different NADES were prepared using mainly food grade constituents and were tested as solvents for the alkaloid berberine. Three selected NADES/berberine solutions and an aqueous suspension were orally administered to mice with in dose of 50 mg/Kg. Blood levels of berberine were measured by a LC-MS/MS method. The pharmacokinetic analysis revealed a 2-20 fold increase in blood concentration of NADES/berberine with significant changes in pharmacokinetic profile. Natural Deep Eutectic Solvents may thus be considered attractive solubilizing agents and may also play a role in the increase of absorption of poorly bioavailable natural products such as berberine.

• Language: English
• Keywords: berberine, NADES, HPLC-MS/MS, pharmacokinetic, in vivo
• Work type: Article
• Typology: 1.01 - Original Scientific Article
• Organization: FFA - Faculty of Pharmacy
• Publication status: Published
• Publication version: Version of Record
• Year: 2017
• Number of pages: 11 str.
• Numbering: Vol. 22, iss. 11, art. 1921
• PID: 20.500.12556/RUL-131003
• UDC: 577.1:547.587.53
• ISSN on article: 1420-3049
• DOI: 10.3390/molecules22111921
• COBISS.SI-ID: 4427377
• Publication date in RUL: 21.09.2021

Record is a part of a journal

• Title: Molecules
• Shortened title: Molecules
• Publisher: MDPI
• ISSN: 1420-3049
• COBISS.SI-ID: 18462981

Licences

• License: CC BY 4.0, Creative Commons Attribution 4.0 International
• Link: http://creativecommons.org/licenses/by/4.0/
• Description: This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.
• Licensing start date: 08.11.2017

Secondary language

• Language: Slovenian
• Keywords: farmakokinetika, lovilci prostih radikalov

Projects

• Funder: Other - Other funder or multiple funders
• Funding programme: MIUR