Bacteria of the genus Bacillus as a source of antiviral agents

Kovachevikj, Miona (author), Danevčič, Tjaša (mentor)

The growing number of multidrug-resistant pathogens leads to the need for novel antimicrobial compounds that could replace or be used in conjunction with existing antimicrobial drugs. Antimicrobial compounds derived from the genus Bacillus show promising antiviral activity and could be a solution to this problem. Bacillus subtilis is a powerful source of antiviral agents such as surfactin, peptides and other extracts that have promising antiviral activity against influenza virus, transmissible gastroenteritis virus, hepatitis C virus, herpes simplex virus, suid herpes virus, vesicular stomatitis virus and simian immunodeficiency virus. Ribonuclease derived from Bacillus pumilus has noteworthy antiviral activity against human respiratory RNA viruses, such as influenza A virus and human rhinovirus, and against phytopathogenic RNA-viruses. Bacillus amyloliquefaciens produces the antiviral peptide subtilosin, which can inhibit the viral replication of herpes simplex virus 1. Surfactin like extract-BLFP, derived from Bacillus licheniformis, acts antivirally against porcine epidemic diarrhea virus. Infected pigs treated with BLFP have only mild symptoms.

• Language: English
• Keywords: Bacillus, antimicrobial peptide, antiviral agent, surfactin, subtilosin
• Work type: Bachelor thesis/paper
• Typology: 2.11 - Undergraduate Thesis
• Organization: BF - Biotechnical Faculty
• Place of publishing: Ljubljana
• Publisher: [M. Kovachevikj]
• Year: 2021
• PID: 20.500.12556/RUL-130187
• UDC: 602.3:579.852.11:604.4:615.33:578.8(043.2)
• COBISS.SI-ID: 76645891
• Publication date in RUL: 11.09.2021

Secondary language

• Language: Slovenian
• Title: Bakterije iz rodu Bacillus kot vir protivirusnih spojin

Abstract

Vse večje število patogenov z odpornostjo na obstoječa zdravila, vodi v potrebo po iskanju novih protimikrobnih spojinah, ki lahko nadomestijo ali se uporabljajo skupaj s tradicionalnimi protimikrobnimi zdravili. Protimikrobne spojine, pridobljene iz rodu Bacillus, kažejo obetavno protivirusno delovanje in bi lahko bile rešitev tega problema. Bakterija Bacillus subtilis je močan vir protivirusnih spojin, kot so surfaktin, peptidi in drugi ekstrakti, ki imajo obetavno protivirusno delovanje proti virusom gripe, virusom prenosljivega gastroenteritisa, virusom hepatitisa C, virusom herpes simpleksa, virusom suid herpesa, virusom vezikularnega stomatitisa in simian virusom imunske pomanjkljivosti. Ribonukleaza, pridobljena iz bakterije Bacillus pumilus, ima protivirusno delovanje proti humanim respiratornim RNA virusom, kot sta prašičja gripa in človeški rinovirus ter proti fitopatogenimi RNA virusom. Bakterija Bacillus amyloliquefaciens proizvaja protivirusni peptid subtilosin, ki lahko zavira razmnoževanje virusa herpes simpleksa 1. Surfaktinu podobni ekstrakt - BLFP, pridobljen iz bakterije Bacillus licheniformis, deluje protivirusno proti virusu epidemije prašičje diareje. Okuženi prašiči, ki so zdravljeni z ekstraktom BLFP, imajo le blage klinične simptome.

• Keywords: Bacillus, protimikrobni peptid, protivirusna spojina, surfactin, subtilosin