Renal alterations in feline immunodeficiency virus (FIV)-infected cats : a natural model of lentivirus-induced renal disease changes

Poli, Alessandro (avtor), Tozon, Nataša (avtor), Guidi, Grazia (avtor), Pistello, Mauro (avtor)

Human immunodeficiency virus (HIV) is associated with several renal syndromes including acute and chronic renal failures, but the underlying pathogenic mechanisms are unclear. HIV and feline immunodeficiency virus (FIV) share numerous biological and pathological features, including renal alterations. We investigated and compared the morphological changes of renal tissue of 51 experimentally and 21 naturally infected cats. Compared to the latter, the experimentally infected cats exhibited some mesangial widening and glomerulonephritis, milder proteinuria, and lower tubular and interstitial alterations. The numbers of giant protein tubular casts and tubular microcysts were also lower. In contrast, diffuse interstitial infiltrates and glomerular and interstitial amyloidosis were detected only in naturally infected cats. Similar alterations are found in HIV infected patients, thus supporting the idea of a causative role of FIV infection in renal disease, and underlining the relevance of the FIV and its natural host as an animal model for investigating lentivirus-associated nephropathy.

• Jezik: Angleški jezik
• Ključne besede: cat, feline immunodeficiency virus, FIV, kidney diseases, renal pathology
• Vrsta gradiva: Članek v reviji
• Tipologija: 1.01 - Izvirni znanstveni članek
• Organizacija: VF - Veterinarska fakulteta
• Status publikacije: Objavljeno
• Različica publikacije: Objavljena publikacija
• Leto izida: 2012
• Št. strani: Str. 1372-1389
• Številčenje: Vol. 4, iss. 9
• PID: 20.500.12556/RUL-129513
• UDK: 616
• ISSN pri članku: 1999-4915
• DOI: 10.3390/v4091372
• COBISS.SI-ID: 3576954
• Datum objave v RUL: 03.09.2021

Gradivo je del revije

• Naslov: Viruses
• Skrajšan naslov: Viruses
• Založnik: MDPI
• ISSN: 1999-4915
• COBISS.SI-ID: 517597977

Licence

• Licenca: CC BY 3.0, Creative Commons Priznanje avtorstva 3.0 Nedoločena
• Povezava: https://creativecommons.org/licenses/by/3.0/deed.sl
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• Začetek licenciranja: 01.09.2012

Projekti

• Financer: Drugi - Drug financer ali več financerjev
• Program financ.: Ministero della Salute-Istituto Superiore di Sanità, IV° Programma Nazionale di Ricerca sull’AIDS
• Naslov: Progetto Nazionale AIDS-Italian Concerted for AIDS Vaccination