Assessing spectral imaging of the human finger for detection of arthritis

Dolenec, Rok (author), Laistler, Elmar (author), Milanič, Matija (author)

Rheumatoid arthritis causes changes in the optical properties of tissues in the joints, which could be detected using spectral imaging. This has the potential for development of low cost, non-contact method for early detection of the disease. In this work, hyperspectral imaging system was used to obtain 24 images of proximal interphalangeal joints of 12 healthy volunteers. A large inter-subject variability was observed, but still an increase in transmittance in the spectral range of 600 nm – 950 nm could be associated to the joint in all images. The results of experiments were compared to detailed simulations of light propagation trough tissue. For the simulations, voxelized 3D models of unaffected and inflamed human joints with realistic tissue distributions were constructed from an in-vivo MRI scan of a healthy human finger. The simulated model of healthy finger successfully reproduced the experimental data, while the affected models indicated that the inflammation introduces detectable differences in the spectral and spatial features. The results were used to guide the design of a dedicated imaging system for detection of rheumatoid arthritis, that will be used in an upcoming clinical study.

• Language: English
• Keywords: medical physics, medical imaging, arthritis, optics
• Work type: Article
• Typology: 1.01 - Original Scientific Article
• Organization: FMF - Faculty of Mathematics and Physics
• Publication status: Published
• Publication version: Version of Record
• Year: 2019
• Number of pages: Str. 6555-6568
• Numbering: Vol. 10, no. 12, art. 379114
• PID: 20.500.12556/RUL-128574
• UDC: 616-073
• ISSN on article: 2156-7085
• DOI: 10.1364/BOE.10.006555
• COBISS.SI-ID: 3386980

Copyright

V članku navedeno: "© 2019 Optical Society of America under the terms of the OSA Open Access Publishing Agreement"; s povezavo https://www.osapublishing.org/library/license_v1.cfm. (20. 7. 2021)

• Publication date in RUL: 20.07.2021

Record is a part of a journal

• Title: Biomedical optics express
• Shortened title: Biomed. opt. express
• Publisher: Optica
• ISSN: 2156-7085
• COBISS.SI-ID: 24857383

Secondary language

• Language: Slovenian
• Keywords: medicinska fizika, medicinsko slikanje, artritis, optika

Projects

• Funder: ARRS - Slovenian Research Agency
• Project number: J2-8171
• Name: Kombinirano multispektralno in termografsko slikanje za presejanje in spremljanje artritisa malih sklepov

• Funder: ARRS - Slovenian Research Agency
• Project number: P1-0389
• Name: Medicinska fizika