Bakrovi kompleksi z izbranimi diketonati

Šubelj, Špela (author), Turel, Iztok (mentor)

Za mnoge bakrove komplekse je bilo dokazano, da izkazujejo antimikrobne in citotoksične lastnosti, zato se še naprej preučujejo kot potencialna terapevtska sredstva. Cilj moje diplomske naloge je bila sinteza in karakterizacija novih bakrovih(II) kompleksov, ki bi bili primerni za nadaljne biološke raziskave. V okviru diplomske naloge sem pripravila štiri bakrove komplekse in jih okarakterizirala s standardnimi metodami – CHN analiza, UV-Vis ter IR. Najprej sem pripravila kompleks, pri katerem sem kot ligand uporabila komercialno dostopen avobenzon, ki se nahaja v sončnih kremah. Ostali kompleksi so bili sintetizirani z ligandi raziskovalne skupine prof. dr. B. Šketa. Slednjim ligandom sem predhodno preverila ustreznost in čistost, in sicer z 1H NMR spektroskopijo. Da bi bili sintetizirani kompleksi primerni za nadaljne raziskave, morajo prav tako ustrezati kriterijem čistosti, kar sem preverila s CHN elementno analizo. Kot ostali dve metodi karakterizacije sem uporabila UV-Vis spektroskopijo in IR spektroskopijo. En primer kompleksa sem analizirala tudi z jedrsko magnetno resonanco (NMR), v dokaz, da ta možnost karakterizacije ni primerna za bakrove komplekse, saj so le ti paramagnetni. Vse sintetizirane komplekse sem poskušala tudi kristalizirati iz različnih topil. Ob tem žal niso nastali dovolj kakovostni kristali, da bi bilo moč določiti njihove strukture v trdnem stanju.

• Language: Slovenian
• Keywords: bakrovi kompleksi, sinteza, karakterizacija, O, O-ligandi, avobenzon, kurkuminoidi
• Work type: Bachelor thesis/paper
• Typology: 2.11 - Undergraduate Thesis
• Organization: FKKT - Faculty of Chemistry and Chemical Technology
• Year: 2020
• PID: 20.500.12556/RUL-124096
• COBISS.SI-ID: 45886979
• Publication date in RUL: 29.12.2020

Secondary language

• Language: English
• Title: Copper complexes with diketonates

Abstract

Antimicrobial and cytotoxic properties are well known for copper complexes which are thus researched as potential therapeutic agents. The aim of my thesis was synthesis and characterization of new copper complexes, which could be suitable for further biological investigations. I have prepared four copper complexes and characterized them with standard techniques – CHN analysis, UV-Vis and IR. First, I have synthesized complex, for which I used commercially available ligand avobenzone, which can be found in sunscreens. Further complexes were prepared with the ligands of the research group of prof. dr. B. Šket. The latter were initially checked for suitability and purity by 1H NMR and mass spectroscopy. Prepared complexes also need to suite purity criteria for further research and were therefore characterized by elemental CHN analysis. Additionally, UV-Vis and IR spectroscopy were performed. In case of copper complexes nuclear magnetic resonance (NMR) cannot be used as a characterization tool as this kind of compounds are paramagnetic. I have tried to obtain suitable crystals for all the synthesized complexes. Unfortunately, crystals of sufficient quality were not formed so we were not able to determine their structures in the solid state.

• Keywords: copper complexes, synthesis, characterization, O, O-ligands, avobenzone, curcuminoids.