Case report: intoxication in a pig (Sus scrofa domesticus) after transdermal fentanyl patch ingestion

Sredenšek, Jerneja (author), Bošnjak, Maša (author), Lampreht Tratar, Urša (author), Kosjek, Tina (author), Čemažar, Maja (author), Kržan, Mojca (author), Seliškar, Alenka (author)

An experimental study on the effects of electroporation on pancreatic tissue was performed in pigs, and the fentanyl transdermal patch (FTP) was used postoperatively as part of multimodal pain management. Ingestion of an FTP, which resulted in fentanyl intoxication, was suspected 5 days after placement in one of the experimental pigs. The pig was first dysphoric, running in the stall, panting and vocalizing until it finally became depressed and it remained lying on the floor. Ingestion of an FTP was not observed but the fentanyl plasma concentration on the day of intoxication was 20.7 ng/ml, while at its peak after FTP administration it was only 0.492 ng/ml. The intoxication was successfully treated with a single intramuscular naloxone injection.

• Language: English
• Keywords: intoxication, pharmacokinetics, naloxone-opioid overdose, swine, pig, fentanyl transdermal patch, pharmacological phenomena, toxicological phenomena, fentanyl
• Work type: Article
• Typology: 1.01 - Original Scientific Article
• Organization: VF - Veterinary Faculty; MF - Faculty of Medicine
• Publication status: Published
• Publication version: Version of Record
• Year: 2020
• Number of pages: 6 str.
• Numbering: Vol. 7, art. 611097
• PID: 20.500.12556/RUL-122241
• UDC: 636.4.09:616.3:615.9
• ISSN on article: 2297-1769
• DOI: 10.3389/fvets.2020.611097
• COBISS.SI-ID: 36219907
• Publication date in RUL: 30.11.2020

Record is a part of a journal

• Title: Frontiers in veterinary science
• Shortened title: Front. vet. sci.
• Publisher: Frontiers Media
• ISSN: 2297-1769
• COBISS.SI-ID: 3969402

Licences

• License: CC BY 4.0, Creative Commons Attribution 4.0 International
• Link: http://creativecommons.org/licenses/by/4.0/
• Description: This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.

Secondary language

• Language: Slovenian
• Keywords: zastrupitev, farmakokinetika, nalokson-opioidno predoziranje, prašiči