Pharmacokinetics/pharmacodynamics of antiviral agents used to treat SARS-CoV-2 and their potential interaction with drugs and other supportive measures : a comprehensive review by the PK/PD of anti-infectives study group of the European Society of Antimicrobial Agents

Zeitlinger, Markus (avtor), Koch, Birgit C. P. (avtor), Bruggemann, Roger (avtor), De Cock, Pieter (avtor), Felton, Timothy (avtor), Hites, Maya (avtor), Le, Jennifer (avtor), Luque, Sonia (avtor), MacGowan, Alasdair P. (avtor), Marriott, Deborah J. E. (avtor), Nadrah, Kristina (avtor)

There is an urgent need to identify optimal antiviral therapies for COVID-19 caused by SARS-CoV-2. We have conducted a rapid and comprehensive review of relevant pharmacological evidence, focusing on (1) the pharmacokinetics (PK) of potential antiviral therapies; (2) coronavirus-specific pharmacodynamics (PD); (3) PK and PD interactions between proposed combination therapies; (4) pharmacology of major supportive therapies; and (5) anticipated drug%drug interactions (DDIs). We found promising in vitro evidence for remdesivir, (hydroxy)chloroquine and favipiravir against SARS-CoV-2; potential clinical benefit in SARS-CoV-2 with remdesivir, the combination of lopinavir/ritonavir (LPV/r) plus ribavirin; and strong evidence for LPV/r plus ribavirin against Middle East Respiratory Syndrome (MERS) for post-exposure prophylaxis in healthcare workers. Despite these emerging data, robust controlled clinical trials assessing patient-centred outcomes remain imperative and clinical data have already reduced expectations with regard to some drugs. Any therapy should be used with caution in the light of potential drug interactions and the uncertainty of optimal doses for treating mild versus serious infections.

• Jezik: Angleški jezik
• Ključne besede: SARS-CoV-2, COVID-19, pharmacokinetics, major supportive therapies
• Tipologija: 1.01 - Izvirni znanstveni članek
• Organizacija: MF - Medicinska fakulteta
• Status publikacije: Objavljeno
• Različica publikacije: Objavljena publikacija
• Leto izida: 2020
• Št. strani: Str. 1159-1216
• Številčenje: Vol. 59, no. 10
• PID: 20.500.12556/RUL-122095
• UDK: 616.9
• ISSN pri članku: 0312-5963
• DOI: 10.1007/s40262-020-00924-9
• COBISS.SI-ID: 29987331
• Datum objave v RUL: 20.11.2020

Gradivo je del revije

• Naslov: Clinical pharmacokinetics
• Skrajšan naslov: Clin. pharmacokinet.
• Založnik: ADIS Press
• ISSN: 0312-5963
• COBISS.SI-ID: 25233152

Licence

• Licenca: CC BY-NC 4.0, Creative Commons Priznanje avtorstva-Nekomercialno 4.0 Mednarodna
• Povezava: http://creativecommons.org/licenses/by-nc/4.0/deed.sl
• Opis: Licenca Creative Commons, ki prepoveduje komercialno uporabo, vendar uporabniki ne rabijo upravljati materialnih avtorskih pravic na izpeljanih delih z enako licenco.
• Začetek licenciranja: 20.11.2020